Names & Taxonomy
- Uniprot ID:
- P11678
- Entry Name:
- PERE_HUMAN
- Status:
- reviewed
- Protein Names:
- Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]
- Gene Names:
- EPX EPER EPO EPP
- Gene Names Primary:
- EPX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 715
- Sequence:
- MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
Function
- Function:
- Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
- Catalytic Activity:
- 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 233 233 Proton acceptor.
- Cross Reference Drug Bank:
- DB01065
- Gene Ontology Go:
- extracellular exosome
heme binding
metal ion binding
peroxidase activity
defense response to nematode
eosinophil migration
hydrogen peroxide catabolic process
negative regulation of interleukin-10 production
negative regulation of interleukin-5 production
positive regulation of interleukin-4 production
response to oxidative stress - Gene Ontology Biological Process:
- defense response to nematode
eosinophil migration
hydrogen peroxide catabolic process
negative regulation of interleukin-10 production
negative regulation of interleukin-5 production
positive regulation of interleukin-4 production
response to oxidative stress - Gene Ontology Molecular Function:
- heme binding
metal ion binding
peroxidase activity - Gene Ontology Cellular Component:
- extracellular exosome
- Keywords:
- Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Iron
Metal-binding
Nitration
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Signal