Names & Taxonomy

Uniprot ID:
P11678
Entry Name:
PERE_HUMAN
Status:
reviewed
Protein Names:
Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]
Gene Names:
EPX EPER EPO EPP
Gene Names Primary:
EPX
Organism:
Homo sapiens (Human)

Structure

Length:
715
Sequence:
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Function

Function:
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Catalytic Activity:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 233 233 Proton acceptor.
Cross Reference Drug Bank:
DB01065
Gene Ontology Go:
extracellular exosome
heme binding
metal ion binding
peroxidase activity
defense response to nematode
eosinophil migration
hydrogen peroxide catabolic process
negative regulation of interleukin-10 production
negative regulation of interleukin-5 production
positive regulation of interleukin-4 production
response to oxidative stress
Gene Ontology Biological Process:
defense response to nematode
eosinophil migration
hydrogen peroxide catabolic process
negative regulation of interleukin-10 production
negative regulation of interleukin-5 production
positive regulation of interleukin-4 production
response to oxidative stress
Gene Ontology Molecular Function:
heme binding
metal ion binding
peroxidase activity
Gene Ontology Cellular Component:
extracellular exosome
Keywords:
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Iron
Metal-binding
Nitration
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Signal

Publication

PubMed ID:
2550461 2541222 10358043 12540536 18694936 7809065 14657871