Names & Taxonomy

Uniprot ID:
P11586
Entry Name:
C1TC_HUMAN
Status:
reviewed
Protein Names:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene Names:
MTHFD1 MTHFC MTHFD
Gene Names Primary:
MTHFD1
Organism:
Homo sapiens (Human)

Structure

Length:
935
Sequence:
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Pathway:
One-carbon metabolism; tetrahydrofolate interconversion.
Catalytic Activity:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.; 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.; ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
Cross Reference Drug Bank:
DB00116
Gene Ontology Go:
cytosol
extracellular exosome
membrane
mitochondrion
ATP binding
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
methylenetetrahydrofolate dehydrogenase activity
10-formyltetrahydrofolate biosynthetic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
folic acid metabolic process
heart development
histidine biosynthetic process
methionine biosynthetic process
methionine metabolic process
neural tube closure
neutrophil homeostasis
one-carbon metabolic process
purine nucleotide biosynthetic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
small molecule metabolic process
somite development
tetrahydrofolate interconversion
transsulfuration
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
10-formyltetrahydrofolate biosynthetic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
folic acid metabolic process
heart development
histidine biosynthetic process
methionine biosynthetic process
methionine metabolic process
neural tube closure
neutrophil homeostasis
one-carbon metabolic process
purine nucleotide biosynthetic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
small molecule metabolic process
somite development
tetrahydrofolate interconversion
transsulfuration
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
ATP binding
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
methylenetetrahydrofolate dehydrogenase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
membrane
mitochondrion
Keywords:
3D-structure
ATP-binding
Acetylation
Amino-acid biosynthesis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Histidine biosynthesis
Hydrolase
Ligase
Methionine biosynthesis
Multifunctional enzyme
NADP
Nucleotide-binding
One-carbon metabolism
Oxidoreductase
Phosphoprotein
Polymorphism
Purine biosynthesis
Reference proteome
Interacts With:
Q9WMX2

Publication

PubMed ID:
3053686 14702039 12508121 15489334 12665801 19413330 21269460 22223895 22814378 24275569 25944712 9519408 10828945 9611072 12384833 16552426 17000706 18767138 21813566 25633902