Names & Taxonomy
- Uniprot ID:
- P11586
- Entry Name:
- C1TC_HUMAN
- Status:
- reviewed
- Protein Names:
- C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
- Gene Names:
- MTHFD1 MTHFC MTHFD
- Gene Names Primary:
- MTHFD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 935
- Sequence:
- MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Pathway:
- One-carbon metabolism; tetrahydrofolate interconversion.
- Catalytic Activity:
- 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.; 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.; ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
mitochondrion
ATP binding
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
methylenetetrahydrofolate dehydrogenase activity
10-formyltetrahydrofolate biosynthetic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
folic acid metabolic process
heart development
histidine biosynthetic process
methionine biosynthetic process
methionine metabolic process
neural tube closure
neutrophil homeostasis
one-carbon metabolic process
purine nucleotide biosynthetic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
small molecule metabolic process
somite development
tetrahydrofolate interconversion
transsulfuration
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- 10-formyltetrahydrofolate biosynthetic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
folic acid metabolic process
heart development
histidine biosynthetic process
methionine biosynthetic process
methionine metabolic process
neural tube closure
neutrophil homeostasis
one-carbon metabolic process
purine nucleotide biosynthetic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
small molecule metabolic process
somite development
tetrahydrofolate interconversion
transsulfuration
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATP binding
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
methylenetetrahydrofolate dehydrogenase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Acetylation
Amino-acid biosynthesis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Histidine biosynthesis
Hydrolase
Ligase
Methionine biosynthesis
Multifunctional enzyme
NADP
Nucleotide-binding
One-carbon metabolism
Oxidoreductase
Phosphoprotein
Polymorphism
Purine biosynthesis
Reference proteome - Interacts With:
- Q9WMX2