Names & Taxonomy
- Uniprot ID:
- P11511
- Entry Name:
- CP19A_HUMAN
- Status:
- reviewed
- Protein Names:
- Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase)
- Gene Names:
- CYP19A1 ARO1 CYAR CYP19
- Gene Names Primary:
- CYP19A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 503
- Sequence:
- MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Peripheral membrane protein.
Function
- Function:
- Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
- Catalytic Activity:
- Testosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.; Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00357 DB01217 DB00443 DB04794 DB06719 DB00389 DB00856 DB00882 DB00257 DB04839 DB01406 DB01234 DB00255 DB00917 DB00858 DB01127 DB00974 DB00292 DB00990 DB01026 DB01006 DB01227 DB00367 DB00358 DB01065 DB00333 DB06710 DB01110 DB08804 DB00984 DB00184 DB01229 DB00481 DB06147 DB00675 DB00857 DB00894 DB00624 DB01007 DB00072
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
membrane
aromatase activity
electron carrier activity
heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
androgen metabolic process
estrogen biosynthetic process
negative regulation of chronic inflammatory response
negative regulation of macrophage chemotaxis
prostate gland growth
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- androgen metabolic process
estrogen biosynthetic process
negative regulation of chronic inflammatory response
negative regulation of macrophage chemotaxis
prostate gland growth
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aromatase activity
electron carrier activity
heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Heme
Iron
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
Polymorphism
Pseudohermaphroditism
Reference proteome