Names & Taxonomy

Uniprot ID:
P11488
Entry Name:
GNAT1_HUMAN
Status:
reviewed
Protein Names:
Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)
Gene Names:
GNAT1 GNATR
Gene Names Primary:
GNAT1
Organism:
Homo sapiens (Human)

Structure

Length:
350
Sequence:
MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Proteomes:
UP000005640

Function

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Gene Ontology Go:
apical plasma membrane
cytosol
heterotrimeric G-protein complex
membrane
neuronal cell body
photoreceptor connecting cilium
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
acyl binding
G-protein beta/gamma-subunit complex binding
G-protein coupled receptor binding
GDP binding
GTP binding
GTPase activity
metal ion binding
protein kinase binding
signal transducer activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell proliferation
cellular response to electrical stimulus
detection of chemical stimulus involved in sensory perception of bitter taste
detection of light stimulus involved in visual perception
eye photoreceptor cell development
negative regulation of cyclic-nucleotide phosphodiesterase activity
phototransduction, visible light
positive regulation of cyclic-nucleotide phosphodiesterase activity
regulation of rhodopsin mediated signaling pathway
response to light intensity
response to light stimulus
retina development in camera-type eye
rhodopsin mediated signaling pathway
sensory perception of umami taste
signal transduction
visual perception
Gene Ontology Biological Process:
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell proliferation
cellular response to electrical stimulus
detection of chemical stimulus involved in sensory perception of bitter taste
detection of light stimulus involved in visual perception
eye photoreceptor cell development
negative regulation of cyclic-nucleotide phosphodiesterase activity
phototransduction, visible light
positive regulation of cyclic-nucleotide phosphodiesterase activity
regulation of rhodopsin mediated signaling pathway
response to light intensity
response to light stimulus
retina development in camera-type eye
rhodopsin mediated signaling pathway
sensory perception of umami taste
signal transduction
visual perception
Gene Ontology Molecular Function:
acyl binding
GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled receptor binding
GTPase activity
GTP binding
metal ion binding
protein kinase binding
signal transducer activity
Gene Ontology Cellular Component:
apical plasma membrane
cytosol
heterotrimeric G-protein complex
membrane
neuronal cell body
photoreceptor connecting cilium
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
Keywords:
3D-structure
ADP-ribosylation
Complete proteome
Congenital stationary night blindness
Disease mutation
GTP-binding
Lipoprotein
Magnesium
Metal-binding
Myristate
Nucleotide-binding
Phosphoprotein
Reference proteome
Sensory transduction
Transducer
Vision

Publication

PubMed ID:
1614872 2534964 2748346 16641997 15489334 11032890 17584859 22190596 8673138 21642972