Names & Taxonomy
- Uniprot ID:
- P11474
- Entry Name:
- ERR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
- Gene Names:
- ESRRA ERR1 ESRL1 NR3B1
- Gene Names Primary:
- ESRRA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 423
- Sequence:
- MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
- Gene Ontology Go:
- intercellular bridge
microtubule cytoskeleton
nucleolus
nucleoplasm
nucleus
DNA binding
protein domain specific binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding
cartilage development
gene expression
intracellular receptor signaling pathway
mitochondrion organization
organelle organization
positive regulation of cellular response to insulin stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
regulation of osteoblast differentiation
regulation of osteoclast differentiation
regulation of transcription, DNA-templated
response to estradiol
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cartilage development
gene expression
intracellular receptor signaling pathway
mitochondrion organization
organelle organization
positive regulation of cellular response to insulin stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of cell proliferation
regulation of osteoblast differentiation
regulation of osteoclast differentiation
regulation of transcription, DNA-templated
response to estradiol
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- DNA binding
protein domain specific binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
zinc ion binding - Gene Ontology Cellular Component:
- intercellular bridge
microtubule cytoskeleton
nucleolus
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Direct protein sequencing
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Q9Y4A5