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Names & Taxonomy

Uniprot ID:: P11413
Entry Name:: G6PD_HUMAN
Status:: reviewed
Protein Names:: Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)
Gene Names:: G6PD
Gene Names Primary:: G6PD
Organism:: Homo sapiens (Human)

Structure

Length:: 515
Sequence:: MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
Proteomes:: UP000005640

Function

Function:: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Pathway:: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Catalytic Activity:: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH.
Kinetics:: BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.07 uM for NADP
Active Site:: ACT_SITE 263 263 Proton acceptor.
Gene Ontology Go:: centrosome
cytoplasm
cytoplasmic side of plasma membrane
cytosol
extracellular exosome
intracellular membrane-bounded organelle
membrane
microtubule organizing center
nucleus
glucose binding
glucose-6-phosphate dehydrogenase activity
identical protein binding
NADP binding
protein homodimerization activity
carbohydrate metabolic process
cellular response to oxidative stress
cholesterol biosynthetic process
erythrocyte maturation
gene expression
glucose 6-phosphate metabolic process
glucose metabolic process
glutathione metabolic process
lipid metabolic process
NADP metabolic process
NADPH regeneration
negative regulation of protein glutathionylation
oxidation-reduction process
pentose biosynthetic process
pentose-phosphate shunt
pentose-phosphate shunt, oxidative branch
regulation of neuron apoptotic process
response to ethanol
response to food
response to organic cyclic compound
ribose phosphate biosynthetic process
small molecule metabolic process
substantia nigra development
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:: carbohydrate metabolic process
cellular response to oxidative stress
cholesterol biosynthetic process
erythrocyte maturation
gene expression
glucose 6-phosphate metabolic process
glucose metabolic process
glutathione metabolic process
lipid metabolic process
NADPH regeneration
NADP metabolic process
negative regulation of protein glutathionylation
oxidation-reduction process
pentose biosynthetic process
pentose-phosphate shunt
pentose-phosphate shunt, oxidative branch
regulation of neuron apoptotic process
response to ethanol
response to food
response to organic cyclic compound
ribose phosphate biosynthetic process
small molecule metabolic process
substantia nigra development
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:: glucose-6-phosphate dehydrogenase activity
glucose binding
identical protein binding
NADP binding
protein homodimerization activity
Gene Ontology Cellular Component:: centrosome
cytoplasm
cytoplasmic side of plasma membrane
cytosol
extracellular exosome
intracellular membrane-bounded organelle
membrane
microtubule organizing center
nucleus
Keywords:: 3D-structure
Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Disease mutation
Glucose metabolism
Hereditary hemolytic anemia
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:: Itself; P04792; Q8IXJ6

Names & Taxonomy

Structure

Function

Publication