Names & Taxonomy
- Uniprot ID:
- P11274
- Entry Name:
- BCR_HUMAN
- Status:
- reviewed
- Protein Names:
- Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
- Gene Names:
- BCR BCR1 D22S11
- Gene Names Primary:
- BCR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1271
- Sequence:
- MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Function
- Function:
- GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cross Reference Drug Bank:
- DB06616 DB08901
- Gene Ontology Go:
- cell junction
cytosol
extracellular exosome
membrane
postsynaptic density
postsynaptic membrane
protein complex
ATP binding
GTPase activator activity
kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
Rho guanyl-nucleotide exchange factor activity
actin cytoskeleton organization
brain development
inner ear morphogenesis
negative regulation of blood vessel remodeling
negative regulation of cellular extravasation
negative regulation of inflammatory response
negative regulation of neutrophil degranulation
neuromuscular process controlling balance
peptidyl-tyrosine phosphorylation
platelet-derived growth factor receptor signaling pathway
positive regulation of phagocytosis
protein autophosphorylation
protein phosphorylation
regulation of cell cycle
regulation of Rho protein signal transduction
regulation of small GTPase mediated signal transduction
regulation of vascular permeability
response to lipopolysaccharide
signal transduction
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- actin cytoskeleton organization
brain development
inner ear morphogenesis
negative regulation of blood vessel remodeling
negative regulation of cellular extravasation
negative regulation of inflammatory response
negative regulation of neutrophil degranulation
neuromuscular process controlling balance
peptidyl-tyrosine phosphorylation
platelet-derived growth factor receptor signaling pathway
positive regulation of phagocytosis
protein autophosphorylation
protein phosphorylation
regulation of cell cycle
regulation of Rho protein signal transduction
regulation of small GTPase mediated signal transduction
regulation of vascular permeability
response to lipopolysaccharide
signal transduction
small GTPase mediated signal transduction - Gene Ontology Molecular Function:
- ATP binding
GTPase activator activity
kinase activity
protein serine/threonine kinase activity
protein tyrosine kinase activity
Rho guanyl-nucleotide exchange factor activity - Gene Ontology Cellular Component:
- cell junction
cytosol
extracellular exosome
membrane
postsynaptic density
postsynaptic membrane
protein complex - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell junction
Cell membrane
Chromosomal rearrangement
Complete proteome
GTPase activation
Guanine-nucleotide releasing factor
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Synapse
Transferase - Interacts With:
- P62993; P18031; Q9H2K2; P04637