Names & Taxonomy

Uniprot ID:
P11233
Entry Name:
RALA_HUMAN
Status:
reviewed
Protein Names:
Ras-related protein Ral-A
Gene Names:
RALA RAL
Gene Names Primary:
RALA
Organism:
Homo sapiens (Human)

Structure

Length:
206
Sequence:
MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.

Function

Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
Enzyme Regulation:
ENZYME REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
Gene Ontology Go:
cell surface
cleavage furrow
cytoplasmic vesicle membrane
extracellular exosome
focal adhesion
midbody
myelin sheath
plasma membrane
ATPase binding
Edg-2 lysophosphatidic acid receptor binding
GDP binding
GTP binding
GTPase activity
myosin binding
ubiquitin protein ligase binding
actin cytoskeleton reorganization
chemotaxis
cytokinesis
exocytosis
membrane organization
membrane raft localization
neural tube closure
neurotrophin TRK receptor signaling pathway
positive regulation of filopodium assembly
Ras protein signal transduction
regulation of exocytosis
signal transduction
viral process
Gene Ontology Biological Process:
actin cytoskeleton reorganization
chemotaxis
cytokinesis
exocytosis
membrane organization
membrane raft localization
neural tube closure
neurotrophin TRK receptor signaling pathway
positive regulation of filopodium assembly
Ras protein signal transduction
regulation of exocytosis
signal transduction
viral process
Gene Ontology Molecular Function:
ATPase binding
Edg-2 lysophosphatidic acid receptor binding
GDP binding
GTPase activity
GTP binding
myosin binding
ubiquitin protein ligase binding
Gene Ontology Cellular Component:
cell surface
cleavage furrow
cytoplasmic vesicle membrane
extracellular exosome
focal adhesion
midbody
myelin sheath
plasma membrane
Keywords:
3D-structure
Cell cycle
Cell division
Cell membrane
Complete proteome
Exocytosis
GTP-binding
Host-virus interaction
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Prenylation
Reference proteome
Interacts With:
O54921; P30154

Publication

PubMed ID:
2662142 2550440 12690205 12853948 15489334 1903399 7673236 10747847 14525976 17875936 18756269 19306925 20005108 21269460 25944712 15920473 16177825 15809419