Names & Taxonomy
- Uniprot ID:
- P11233
- Entry Name:
- RALA_HUMAN
- Status:
- reviewed
- Protein Names:
- Ras-related protein Ral-A
- Gene Names:
- RALA RAL
- Gene Names Primary:
- RALA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 206
- Sequence:
- MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.
Function
- Function:
- Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
- Enzyme Regulation:
- ENZYME REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
- Gene Ontology Go:
- cell surface
cleavage furrow
cytoplasmic vesicle membrane
extracellular exosome
focal adhesion
midbody
myelin sheath
plasma membrane
ATPase binding
Edg-2 lysophosphatidic acid receptor binding
GDP binding
GTP binding
GTPase activity
myosin binding
ubiquitin protein ligase binding
actin cytoskeleton reorganization
chemotaxis
cytokinesis
exocytosis
membrane organization
membrane raft localization
neural tube closure
neurotrophin TRK receptor signaling pathway
positive regulation of filopodium assembly
Ras protein signal transduction
regulation of exocytosis
signal transduction
viral process - Gene Ontology Biological Process:
- actin cytoskeleton reorganization
chemotaxis
cytokinesis
exocytosis
membrane organization
membrane raft localization
neural tube closure
neurotrophin TRK receptor signaling pathway
positive regulation of filopodium assembly
Ras protein signal transduction
regulation of exocytosis
signal transduction
viral process - Gene Ontology Molecular Function:
- ATPase binding
Edg-2 lysophosphatidic acid receptor binding
GDP binding
GTPase activity
GTP binding
myosin binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cell surface
cleavage furrow
cytoplasmic vesicle membrane
extracellular exosome
focal adhesion
midbody
myelin sheath
plasma membrane - Keywords:
- 3D-structure
Cell cycle
Cell division
Cell membrane
Complete proteome
Exocytosis
GTP-binding
Host-virus interaction
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Prenylation
Reference proteome - Interacts With:
- O54921; P30154