Names & Taxonomy
- Uniprot ID:
- P11226
- Entry Name:
- MBL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)
- Gene Names:
- MBL2 COLEC1 MBL
- Gene Names Primary:
- MBL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 248
- Sequence:
- MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
- Gene Ontology Go:
- cell surface
collagen trimer
extracellular region
extracellular space
calcium ion binding
calcium-dependent protein binding
mannose binding
receptor binding
acute-phase response
complement activation
complement activation, classical pathway
complement activation, lectin pathway
defense response to bacterium
defense response to Gram-positive bacterium
innate immune response
killing by host of symbiont cells
negative regulation of growth of symbiont in host
negative regulation of viral process
opsonization
positive regulation of phagocytosis
response to oxidative stress - Gene Ontology Biological Process:
- acute-phase response
complement activation
complement activation, classical pathway
complement activation, lectin pathway
defense response to bacterium
defense response to Gram-positive bacterium
innate immune response
killing by host of symbiont cells
negative regulation of growth of symbiont in host
negative regulation of viral process
opsonization
positive regulation of phagocytosis
response to oxidative stress - Gene Ontology Molecular Function:
- calcium-dependent protein binding
calcium ion binding
mannose binding
receptor binding - Gene Ontology Cellular Component:
- cell surface
collagen trimer
extracellular region
extracellular space - Keywords:
- 3D-structure
Calcium
Coiled coil
Collagen
Complement activation lectin pathway
Complement pathway
Complete proteome
Direct protein sequencing
Disulfide bond
Hydroxylation
Immunity
Innate immunity
Lectin
Mannose-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- Q07954