Names & Taxonomy
- Uniprot ID:
- P11217
- Entry Name:
- PYGM_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)
- Gene Names:
- PYGM
- Gene Names Primary:
- PYGM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 842
- Sequence:
- MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI
- Proteomes:
- UP000005640
Function
- Function:
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
- Catalytic Activity:
- ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Enzyme Regulation:
- ENZYME REGULATION: Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
sarcoplasmic reticulum
AMP binding
carbohydrate binding
drug binding
glycogen phosphorylase activity
pyridoxal phosphate binding
carbohydrate metabolic process
cellular calcium ion homeostasis
glucose metabolic process
glycogen catabolic process
glycogen metabolic process
response to cAMP
response to hypoxia
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular calcium ion homeostasis
glucose metabolic process
glycogen catabolic process
glycogen metabolic process
response to cAMP
response to hypoxia
small molecule metabolic process - Gene Ontology Molecular Function:
- AMP binding
carbohydrate binding
drug binding
glycogen phosphorylase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
sarcoplasmic reticulum - Keywords:
- 3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Carbohydrate metabolism
Complete proteome
Disease mutation
Glycogen metabolism
Glycogen storage disease
Glycosyltransferase
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- O43741; Q96HA8