Names & Taxonomy

Uniprot ID:
P11215
Entry Name:
ITAM_HUMAN
Status:
reviewed
Protein Names:
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
Gene Names:
ITGAM CD11B CR3A
Gene Names Primary:
ITGAM
Organism:
Homo sapiens (Human)

Structure

Length:
1152
Sequence:
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Gene Ontology Go:
cell surface
extracellular exosome
extracellular space
integrin complex
plasma membrane
glycoprotein binding
metal ion binding
blood coagulation
cell adhesion
ectodermal cell differentiation
extracellular matrix organization
innate immune response
integrin-mediated signaling pathway
leukocyte migration
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Biological Process:
blood coagulation
cell adhesion
ectodermal cell differentiation
extracellular matrix organization
innate immune response
integrin-mediated signaling pathway
leukocyte migration
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Molecular Function:
glycoprotein binding
metal ion binding
Gene Ontology Cellular Component:
cell surface
extracellular exosome
extracellular space
integrin complex
plasma membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2457584 2833753 2454931 8419480 15489334 2563162 1683702 1346576 3539202 12208882 15194813 19159218 7867070 8747460 9687375 9560195 18204448 18204446