Names & Taxonomy
- Uniprot ID:
- P11215
- Entry Name:
- ITAM_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
- Gene Names:
- ITGAM CD11B CR3A
- Gene Names Primary:
- ITGAM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1152
- Sequence:
- MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
- Gene Ontology Go:
- cell surface
extracellular exosome
extracellular space
integrin complex
plasma membrane
glycoprotein binding
metal ion binding
blood coagulation
cell adhesion
ectodermal cell differentiation
extracellular matrix organization
innate immune response
integrin-mediated signaling pathway
leukocyte migration
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- blood coagulation
cell adhesion
ectodermal cell differentiation
extracellular matrix organization
innate immune response
integrin-mediated signaling pathway
leukocyte migration
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- glycoprotein binding
metal ion binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
extracellular space
integrin complex
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix