Names & Taxonomy
- Uniprot ID:
- P11177
- Entry Name:
- ODPB_HUMAN
- Status:
- reviewed
- Protein Names:
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
- Gene Names:
- PDHB PHE1B
- Gene Names Primary:
- PDHB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
- Catalytic Activity:
- Pyruvate + lipoyllysine = S-acetyldihydrolipoyllysine + CO(2).
- Cofactor:
- COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
- Cross Reference Drug Bank:
- DB00119
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus
pyruvate dehydrogenase complex
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase activity
acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus
pyruvate dehydrogenase complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Disease mutation
Glucose metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Pyruvate
Reference proteome
Thiamine pyrophosphate
Transit peptide
Tricarboxylic acid cycle - Interacts With:
- P10515