Names & Taxonomy
- Uniprot ID:
- P11168
- Entry Name:
- GTR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)
- Gene Names:
- SLC2A2 GLUT2
- Gene Names Primary:
- SLC2A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
- Cross Reference Drug Bank:
- DB00428
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell-cell junction
cytosol
endosome
integral component of plasma membrane
membrane
plasma membrane
D-glucose transmembrane transporter activity
dehydroascorbic acid transporter activity
glucose transmembrane transporter activity
hexose transmembrane transporter activity
carbohydrate metabolic process
carbohydrate utilization
endocrine pancreas development
energy reserve metabolic process
fructose transport
glucose transport
hexose transport
regulation of insulin secretion
response to glucose
response to peptide hormone
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- carbohydrate metabolic process
carbohydrate utilization
endocrine pancreas development
energy reserve metabolic process
fructose transport
glucose transport
hexose transport
regulation of insulin secretion
response to glucose
response to peptide hormone
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- dehydroascorbic acid transporter activity
D-glucose transmembrane transporter activity
glucose transmembrane transporter activity
hexose transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell-cell junction
cytosol
endosome
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport