Names & Taxonomy

Uniprot ID:
P10828
Entry Name:
THB_HUMAN
Status:
reviewed
Protein Names:
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene Names:
THRB ERBA2 NR1A2 THR1
Gene Names Primary:
THRB
Organism:
Homo sapiens (Human)

Structure

Length:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus.

Function

Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Cross Reference Drug Bank:
DB00509 DB00451 DB00279 DB01583
Gene Ontology Go:
extracellular exosome
nuclear chromatin
nucleoplasm
nucleus
chromatin DNA binding
DNA binding
enzyme binding
sequence-specific DNA binding
steroid hormone receptor activity
thyroid hormone binding
thyroid hormone receptor activity
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
female courtship behavior
gene expression
intracellular receptor signaling pathway
negative regulation of female receptivity
negative regulation of transcription from RNA polymerase II promoter
organ morphogenesis
positive regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
sensory perception of sound
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
Type I pneumocyte differentiation
Gene Ontology Biological Process:
female courtship behavior
gene expression
intracellular receptor signaling pathway
negative regulation of female receptivity
negative regulation of transcription from RNA polymerase II promoter
organ morphogenesis
positive regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
sensory perception of sound
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
Type I pneumocyte differentiation
Gene Ontology Molecular Function:
chromatin DNA binding
DNA binding
enzyme binding
sequence-specific DNA binding
steroid hormone receptor activity
thyroid hormone binding
thyroid hormone receptor activity
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
Gene Ontology Cellular Component:
extracellular exosome
nuclear chromatin
nucleoplasm
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
DNA-binding
Deafness
Disease mutation
Metal-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger

Publication

PubMed ID:
3034496 2879243 1973914 14702039 16641997 15489334 15105435 7528740 10713182 12039952 11971969 17418816 7746322 12699376 12511610 12554782 14673100 15466465 16781732 18237438 19926848 18798561 2510172 2153155 1846005 1661299 1653889 1563081 1314846 1619012 1587388 1324420 8381821 8514853 8175986 7833659 8664910 8889584 10660344 16804041 19268523