Names & Taxonomy
- Uniprot ID:
- P10644
- Entry Name:
- KAP0_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]
- Gene Names:
- PRKAR1A PKR1 PRKAR1 TSE1
- Gene Names Primary:
- PRKAR1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 381
- Sequence:
- MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
- Gene Ontology Go:
- cAMP-dependent protein kinase complex
ciliary base
cytoplasm
cytosol
membrane
neuromuscular junction
nucleotide-activated protein kinase complex
plasma membrane raft
protein complex
cAMP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
protein kinase A catalytic subunit binding
ubiquitin protein ligase binding
activation of phospholipase C activity
activation of protein kinase A activity
blood coagulation
cardiac muscle cell proliferation
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
female meiotic division
fibroblast growth factor receptor signaling pathway
innate immune response
intracellular signal transduction
mesoderm formation
negative regulation of activated T cell proliferation
negative regulation of cAMP-dependent protein kinase activity
negative regulation of meiotic nuclear division
neurotrophin TRK receptor signaling pathway
regulation of insulin secretion
regulation of transcription from RNA polymerase II promoter
renal water homeostasis
sarcomere organization
signal transduction
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of phospholipase C activity
activation of protein kinase A activity
blood coagulation
cardiac muscle cell proliferation
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
female meiotic division
fibroblast growth factor receptor signaling pathway
innate immune response
intracellular signal transduction
mesoderm formation
negative regulation of activated T cell proliferation
negative regulation of cAMP-dependent protein kinase activity
negative regulation of meiotic nuclear division
neurotrophin TRK receptor signaling pathway
regulation of insulin secretion
regulation of transcription from RNA polymerase II promoter
renal water homeostasis
sarcomere organization
signal transduction
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Molecular Function:
- cAMP binding
cAMP-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase regulator activity
protein kinase A catalytic subunit binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cAMP-dependent protein kinase complex
ciliary base
cytoplasm
cytosol
membrane
neuromuscular junction
nucleotide-activated protein kinase complex
plasma membrane raft
protein complex - Keywords:
- Acetylation
Alternative splicing
Cell membrane
Complete proteome
Cushing syndrome
Direct protein sequencing
Disease mutation
Disulfide bond
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
Repeat
cAMP
cAMP-binding - Interacts With:
- P03259-2; Q9H0R8; Q9H8W4; P17612; P51817; P35250; Q01105
Publication
- PubMed ID:
- 3426618 2310396 1889088 8977401 16625196 15489334 12665801 12213893 15655353 17081983 16491121 16387847 19367720 18088087 18691976 18669648 18318008 19413330 19369195 19690332 20215566 20068231 21269460 21651393 21423175 21406692 22785148 23115245 23323113 22223895 22814378 24275569 15371594 18241045 22464250 22464252 23043190 22723333 23425300 26405036