Names & Taxonomy
- Uniprot ID:
- P10635
- Entry Name:
- CP2D6_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
- Gene Names:
- CYP2D6 CYP2DL1
- Gene Names Primary:
- CYP2D6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 497
- Sequence:
- MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane
Function
- Function:
- Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB05812 DB01193 DB00316 DB03128 DB01426 DB00918 DB06203 DB00866 DB01424 DB01118 DB00321 DB00381 DB00613 DB00543 DB00182 DB00701 DB00276 DB01435 DB01429 DB01274 DB01238 DB06697 DB06216 DB00637 DB00289 DB01076 DB00972 DB00245 DB06770 DB01244 DB00195 DB01128 DB00810 DB00612 DB00188 DB09128 DB00835 DB00297 DB00921 DB01156 DB00490 DB00201 DB01197 DB00748 DB06016 DB00521 DB01136 DB00482 DB00567 DB00185 DB00475 DB00608 DB01114 DB00477 DB00356 DB00169 DB01410 DB01166 DB00501 DB01012 DB00568 DB00604 DB00215 DB00283 DB04920 DB00349 DB01242 DB00575 DB00257 DB00363 DB09065 DB00907 DB00318 DB00924 DB00531 DB00091 DB06292 DB00496 DB04840 DB00705 DB01151 DB00967 DB01234 DB01191 DB00633 DB06701 DB01576 DB00514 DB00647 DB01551 DB00343 DB01093 DB01075 DB00757 DB01184 DB00843 DB00988 DB00590 DB01142 DB00997 DB04855 DB00476 DB00625 DB00216 DB09039 DB01228 DB08899 DB00751 DB00530 DB01175 DB01466 DB01628 DB01023 DB06702 DB00950 DB08868 DB01195 DB04841 DB00472 DB00623 DB01095 DB00176 DB00983 DB00674 DB00317 DB01437 DB00889 DB01218 DB00502 DB01159 DB00667 DB00956 DB00327 DB01611 DB01005 DB00557 DB09053 DB01177 DB04946 DB00619 DB00458 DB00224 DB00332 DB01029 DB00951 DB01167 DB09570 DB01026 DB00598 DB00448 DB00528 DB01235 DB08918 DB00281 DB00589 DB01206 DB00836 DB01601 DB00455 DB04871 DB00227 DB06708 DB00934 DB00358 DB06691 DB01071 DB00933 DB00333 DB01577 DB00703 DB00763 DB01403 DB01028 DB06800 DB00422 DB01107 DB01233 DB00264 DB00379 DB06148 DB01110 DB00211 DB00834 DB00805 DB08893 DB00370 DB01171 DB00295 DB09049 DB00731 DB04861 DB01149 DB00220 DB09048 DB00238 DB00627 DB00622 DB00699 DB02701 DB00184 DB01115 DB04868 DB00336 DB00540 DB00334 DB00338 DB00904 DB01096 DB01580 DB01062 DB00497 DB06412 DB01192 DB01267 DB00377 DB06603 DB00715 DB06589 DB00738 DB01186 DB01074 DB00850 DB00454 DB00914 DB00191 DB01100 DB00960 DB01132 DB00592 DB01621 DB08901 DB00175 DB01058 DB01087 DB01035 DB00433 DB00396 DB01131 DB01069 DB01182 DB00818 DB00571 DB00344 DB00852 DB00205 DB01224 DB00908 DB00468 DB01129 DB00863 DB00243 DB00234 DB00409 DB01201 DB00734 DB00503 DB00989 DB09291 DB00268 DB00296 DB00412 DB05271 DB01232 DB01037 DB06144 DB01104 DB00203 DB00641 DB00398 DB00259 DB06729 DB00675 DB00706 DB06204 DB00976 DB06287 DB00857 DB04844 DB00277 DB00679 DB01623 DB00208 DB00373 DB01409 DB00932 DB01036 DB05109 DB00193 DB00752 DB00656 DB00726 DB00792 DB00427 DB00209 DB09076 DB08881 DB00285 DB00661 DB06684 DB00570 DB00361 DB09068 DB01392 DB00549 DB00943 DB00246 DB00425 DB01624
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion
arachidonic acid epoxygenase activity
aromatase activity
drug binding
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
steroid hydroxylase activity
alkaloid catabolic process
alkaloid metabolic process
arachidonic acid metabolic process
coumarin metabolic process
drug catabolic process
drug metabolic process
heterocycle metabolic process
isoquinoline alkaloid metabolic process
monoterpenoid metabolic process
negative regulation of binding
negative regulation of cellular organofluorine metabolic process
oxidation-reduction process
oxidative demethylation
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- alkaloid catabolic process
alkaloid metabolic process
arachidonic acid metabolic process
coumarin metabolic process
drug catabolic process
drug metabolic process
heterocycle metabolic process
isoquinoline alkaloid metabolic process
monoterpenoid metabolic process
negative regulation of binding
negative regulation of cellular organofluorine metabolic process
oxidation-reduction process
oxidative demethylation
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- arachidonic acid epoxygenase activity
aromatase activity
drug binding
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity
steroid hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Lipid metabolism
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism