Names & Taxonomy
- Uniprot ID:
- P10620
- Entry Name:
- MGST1_HUMAN
- Status:
- reviewed
- Protein Names:
- Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I)
- Gene Names:
- MGST1 GST12 MGST
- Gene Names Primary:
- MGST1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 155
- Sequence:
- MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Enzyme Regulation:
- ENZYME REGULATION: Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity).
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- apical part of cell
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
nucleus
peroxisomal membrane
glutathione binding
glutathione peroxidase activity
glutathione transferase activity
cellular oxidant detoxification
cellular response to lipid hydroperoxide
glutathione derivative biosynthetic process
glutathione metabolic process
Leydig cell differentiation
oxidation-reduction process
protein homotrimerization
response to drug
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
cellular response to lipid hydroperoxide
glutathione derivative biosynthetic process
glutathione metabolic process
Leydig cell differentiation
oxidation-reduction process
protein homotrimerization
response to drug
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione binding
glutathione peroxidase activity
glutathione transferase activity - Gene Ontology Cellular Component:
- apical part of cell
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
nucleus
peroxisomal membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Microsome
Mitochondrion
Mitochondrion outer membrane
Nitration
Reference proteome
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- Q8WX92