Names & Taxonomy

Uniprot ID:
P10153
Entry Name:
RNAS2_HUMAN
Status:
reviewed
Protein Names:
Non-secretory ribonuclease (EC 3.1.27.5) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)
Gene Names:
RNASE2 EDN RNS2
Gene Names Primary:
RNASE2
Organism:
Homo sapiens (Human)

Structure

Length:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome

Function

Function:
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
Catalytic Activity:
Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Active Site:
ACT_SITE 42 42 Proton acceptor.; ACT_SITE 156 156 Proton donor.
Gene Ontology Go:
extracellular exosome
extracellular region
lysosome
endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity
chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of protein targeting to mitochondrion
RNA catabolic process
RNA phosphodiester bond hydrolysis
Gene Ontology Biological Process:
chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of protein targeting to mitochondrion
RNA catabolic process
RNA phosphodiester bond hydrolysis
Gene Ontology Molecular Function:
endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
lysosome
Keywords:
3D-structure
Chemotaxis
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Lysosome
Nitration
Nuclease
Polymorphism
Reference proteome
Signal

Publication

PubMed ID:
2591744 2745977 2734298 2387583 11102386 15489334 3166997 3458170 3926759 3182786 1587793 8471426 7947762 7547911 9450956 12578357 12855582 18694936 24275569 25944712 8759319 11154698 15755456 16401072