Names & Taxonomy
- Uniprot ID:
- P10153
- Entry Name:
- RNAS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Non-secretory ribonuclease (EC 3.1.27.5) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)
- Gene Names:
- RNASE2 EDN RNS2
- Gene Names Primary:
- RNASE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 161
- Sequence:
- MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Function:
- This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
- Catalytic Activity:
- Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
- Active Site:
- ACT_SITE 42 42 Proton acceptor.; ACT_SITE 156 156 Proton donor.
- Gene Ontology Go:
- extracellular exosome
extracellular region
lysosome
endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity
chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of protein targeting to mitochondrion
RNA catabolic process
RNA phosphodiester bond hydrolysis - Gene Ontology Biological Process:
- chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of protein targeting to mitochondrion
RNA catabolic process
RNA phosphodiester bond hydrolysis - Gene Ontology Molecular Function:
- endonuclease activity
nucleic acid binding
ribonuclease A activity
ribonuclease activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
lysosome - Keywords:
- 3D-structure
Chemotaxis
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Lysosome
Nitration
Nuclease
Polymorphism
Reference proteome
Signal