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Names & Taxonomy

Uniprot ID:: P09874
Entry Name:: PARP1_HUMAN
Status:: reviewed
Protein Names:: Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)
Gene Names:: PARP1 ADPRT PPOL
Gene Names Primary:: PARP1
Organism:: Homo sapiens (Human)

Structure

Length:: 1014
Sequence:: MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.

Function

Function:: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Catalytic Activity:: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Cross Reference Drug Bank:: DB02701 DB09074
Gene Ontology Go:: membrane
mitochondrion
nuclear chromosome, telomeric region
nuclear envelope
nucleolus
nucleoplasm
nucleus
protein complex
transcription factor complex
DNA binding
DNA ligase (ATP) activity
enzyme binding
identical protein binding
NAD binding
NAD+ ADP-ribosyltransferase activity
poly(A) RNA binding
protein kinase binding
protein N-terminus binding
transcription factor binding
zinc ion binding
base-excision repair
cellular protein metabolic process
cellular response to DNA damage stimulus
cellular response to insulin stimulus
cellular response to oxidative stress
DNA damage response, detection of DNA damage
DNA ligation involved in DNA repair
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
gene expression
global genome nucleotide-excision repair
lagging strand elongation
macrophage differentiation
mitochondrial DNA metabolic process
mitochondrial DNA repair
mitochondrion organization
negative regulation of telomere maintenance via telomere lengthening
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA incision
positive regulation of cardiac muscle hypertrophy
positive regulation of SMAD protein import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription regulatory region DNA binding
post-translational protein modification
protein ADP-ribosylation
protein autoprocessing
protein modification process
protein poly-ADP-ribosylation
protein sumoylation
regulation of cellular protein localization
signal transduction involved in regulation of gene expression
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
Gene Ontology Biological Process:: base-excision repair
cellular protein metabolic process
cellular response to DNA damage stimulus
cellular response to insulin stimulus
cellular response to oxidative stress
DNA damage response, detection of DNA damage
DNA ligation involved in DNA repair
DNA repair
double-strand break repair
double-strand break repair via homologous recombination
gene expression
global genome nucleotide-excision repair
lagging strand elongation
macrophage differentiation
mitochondrial DNA metabolic process
mitochondrial DNA repair
mitochondrion organization
negative regulation of telomere maintenance via telomere lengthening
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA incision
positive regulation of cardiac muscle hypertrophy
positive regulation of SMAD protein import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription regulatory region DNA binding
post-translational protein modification
protein ADP-ribosylation
protein autoprocessing
protein modification process
protein poly-ADP-ribosylation
protein sumoylation
regulation of cellular protein localization
signal transduction involved in regulation of gene expression
transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
Gene Ontology Molecular Function:: DNA binding
DNA ligase (ATP) activity
enzyme binding
identical protein binding
NAD+ ADP-ribosyltransferase activity
NAD binding
poly(A) RNA binding
protein kinase binding
protein N-terminus binding
transcription factor binding
zinc ion binding
Gene Ontology Cellular Component:: membrane
mitochondrion
nuclear chromosome, telomeric region
nuclear envelope
nucleolus
nucleoplasm
nucleus
protein complex
transcription factor complex
Keywords:: 3D-structure
ADP-ribosylation
Acetylation
Complete proteome
DNA damage
DNA repair
DNA-binding
Direct protein sequencing
Glycosyltransferase
Isopeptide bond
Metal-binding
NAD
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Transferase
Ubl conjugation
Zinc
Zinc-finger
Interacts With:: Itself; Q8IW19; Q7Z2E3; P49715; Q01094; P11308; Q13007; Q9Y530; Q8N2W9; O95863; Q02085; P63165; P04637; P0CG48; Q14191; P18887; Q2M1K9

Names & Taxonomy

Structure

Subcellular location

Function

Publication