Names & Taxonomy
- Uniprot ID:
- P09848
- Entry Name:
- LPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)]
- Gene Names:
- LCT LPH
- Gene Names Primary:
- LCT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1927
- Sequence:
- MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKDMYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQDTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSLFEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQRIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTTEGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSIIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTISPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQELSPVSSF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Single-pass type I membrane protein. Note=Brush border.
Function
- Function:
- LPH splits lactose in the small intestine.
- Catalytic Activity:
- Lactose + H(2)O = D-galactose + D-glucose.; Glycosyl-N-acylsphingosine + H(2)O = N-acylsphingosine + a sugar.
- Active Site:
- ACT_SITE 1065 1065 Proton donor.
- Cross Reference Drug Bank:
- DB00126
- Gene Ontology Go:
- apical plasma membrane
brush border
integral component of plasma membrane
membrane
plasma membrane
glycosylceramidase activity
lactase activity
transferase activity
carbohydrate metabolic process
polysaccharide digestion
response to drug
response to estrogen
response to ethanol
response to hypoxia
response to iron(II) ion
response to lead ion
response to nickel cation
response to nutrient
response to starvation
response to sucrose
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
polysaccharide digestion
response to drug
response to estrogen
response to ethanol
response to hypoxia
response to iron(II) ion
response to lead ion
response to nickel cation
response to nutrient
response to starvation
response to sucrose
small molecule metabolic process - Gene Ontology Molecular Function:
- glycosylceramidase activity
lactase activity
transferase activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Glycosidase
Hydrolase
Membrane
Multifunctional enzyme
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Zymogen