Names & Taxonomy
- Uniprot ID:
- P09488
- Entry Name:
- GSTM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)
- Gene Names:
- GSTM1 GST1
- Gene Names Primary:
- GSTM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 218
- Sequence:
- MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB00993 DB01008 DB00958 DB00515 DB00143 DB00526
- Gene Ontology Go:
- cytoplasm
cytosol
enzyme binding
glutathione binding
glutathione transferase activity
protein homodimerization activity
cellular detoxification of nitrogen compound
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular detoxification of nitrogen compound
glutathione derivative biosynthetic process
glutathione metabolic process
nitrobenzene metabolic process
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
glutathione binding
glutathione transferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Phosphoprotein
Polymorphism
Reference proteome
Transferase