Names & Taxonomy
- Uniprot ID:
- P09417
- Entry Name:
- DHPR_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1)
- Gene Names:
- QDPR DHPR SDR33C1
- Gene Names Primary:
- QDPR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 244
- Sequence:
- MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF
- Proteomes:
- UP000005640
Function
- Function:
- The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
- Catalytic Activity:
- A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
- Active Site:
- ACT_SITE 150 150 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
neuron projection
6,7-dihydropteridine reductase activity
electron carrier activity
NADH binding
NADPH binding
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to drug
dihydrobiopterin metabolic process
L-phenylalanine catabolic process
liver development
response to aluminum ion
response to glucagon
response to lead ion
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Biological Process:
- cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to drug
dihydrobiopterin metabolic process
liver development
L-phenylalanine catabolic process
response to aluminum ion
response to glucagon
response to lead ion
small molecule metabolic process
tetrahydrobiopterin biosynthetic process - Gene Ontology Molecular Function:
- 6,7-dihydropteridine reductase activity
electron carrier activity
NADH binding
NADPH binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
neuron projection - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
NADP
Oxidoreductase
Phenylketonuria
Polymorphism
Reference proteome
Tetrahydrobiopterin biosynthesis