Names & Taxonomy

Uniprot ID:
P09417
Entry Name:
DHPR_HUMAN
Status:
reviewed
Protein Names:
Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1)
Gene Names:
QDPR DHPR SDR33C1
Gene Names Primary:
QDPR
Organism:
Homo sapiens (Human)

Structure

Length:
244
Sequence:
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF
Proteomes:
UP000005640

Function

Function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
Catalytic Activity:
A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
Active Site:
ACT_SITE 150 150 Proton acceptor.
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
mitochondrion
neuron projection
6,7-dihydropteridine reductase activity
electron carrier activity
NADH binding
NADPH binding
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to drug
dihydrobiopterin metabolic process
L-phenylalanine catabolic process
liver development
response to aluminum ion
response to glucagon
response to lead ion
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
Gene Ontology Biological Process:
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
cellular response to drug
dihydrobiopterin metabolic process
liver development
L-phenylalanine catabolic process
response to aluminum ion
response to glucagon
response to lead ion
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
Gene Ontology Molecular Function:
6,7-dihydropteridine reductase activity
electron carrier activity
NADH binding
NADPH binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
mitochondrion
neuron projection
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
NADP
Oxidoreductase
Phenylketonuria
Polymorphism
Reference proteome
Tetrahydrobiopterin biosynthesis

Publication

PubMed ID:
3031582 3033643 9744478 14702039 15815621 15489334 19413330 21269460 22223895 22814378 24275569 8262916 7627180 8326489 2116088 10408783 11153907