Names & Taxonomy
- Uniprot ID:
- P09382
- Entry Name:
- LEG1_HUMAN
- Status:
- reviewed
- Protein Names:
- Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
- Gene Names:
- LGALS1
- Gene Names Primary:
- LGALS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 135
- Sequence:
- MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular exosome
extracellular space
intracellular
nucleus
proteinaceous extracellular matrix
lactose binding
poly(A) RNA binding
signal transducer activity
apoptotic process
cellular response to glucose stimulus
cellular response to organic cyclic compound
multicellular organismal response to stress
myoblast differentiation
negative regulation of cell-substrate adhesion
negative regulation of neuron projection development
plasma cell differentiation
positive regulation of erythrocyte aggregation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of viral entry into host cell
regulation of apoptotic process
response to axon injury
response to drug
signal transduction
T cell costimulation - Gene Ontology Biological Process:
- apoptotic process
cellular response to glucose stimulus
cellular response to organic cyclic compound
multicellular organismal response to stress
myoblast differentiation
negative regulation of cell-substrate adhesion
negative regulation of neuron projection development
plasma cell differentiation
positive regulation of erythrocyte aggregation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of viral entry into host cell
regulation of apoptotic process
response to axon injury
response to drug
signal transduction
T cell costimulation - Gene Ontology Molecular Function:
- lactose binding
poly(A) RNA binding
signal transducer activity - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular exosome
extracellular space
intracellular
nucleus
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Acetylation
Apoptosis
Complete proteome
Direct protein sequencing
Extracellular matrix
Lectin
Phosphoprotein
Reference proteome
Secreted - Interacts With:
- Q13740; P30203; P35968; P08575
Publication
- PubMed ID:
- 2719964 2910856 2719646 18824694 1988031 12761501 15461802 14702039 10591208 15489334 3065332 12665801 3611046 1386213 2383549 7501023 10369126 10764829 11146440 14617626 19497882 19608861 21269460 22905912 22223895 22814378 23131994 24945728 24275569 26091039 25944712 15476813 18796645 19128029