Names & Taxonomy
- Uniprot ID:
- P09237
- Entry Name:
- MMP7_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)
- Gene Names:
- MMP7 MPSL1 PUMP1
- Gene Names Primary:
- MMP7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 267
- Sequence:
- MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
- Catalytic Activity:
- Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 2 calcium ions per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
- Active Site:
- ACT_SITE 215 215
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- cell surface
extracellular exosome
extracellular region
extracellular space
proteinaceous extracellular matrix
heparin binding
metalloendopeptidase activity
zinc ion binding
aging
cellular response to mechanical stimulus
collagen catabolic process
estrous cycle
extracellular matrix disassembly
extracellular matrix organization
maternal process involved in female pregnancy
proteolysis
response to nutrient levels - Gene Ontology Biological Process:
- aging
cellular response to mechanical stimulus
collagen catabolic process
estrous cycle
extracellular matrix disassembly
extracellular matrix organization
maternal process involved in female pregnancy
proteolysis
response to nutrient levels - Gene Ontology Molecular Function:
- heparin binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen