Names & Taxonomy

Uniprot ID:
P09110
Entry Name:
THIK_HUMAN
Status:
reviewed
Protein Names:
3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)
Gene Names:
ACAA1 ACAA PTHIO
Gene Names Primary:
ACAA1
Organism:
Homo sapiens (Human)

Structure

Length:
424
Sequence:
MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Peroxisome.

Function

Pathway:
Lipid metabolism; fatty acid metabolism.
Catalytic Activity:
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Active Site:
ACT_SITE 123 123 Acyl-thioester intermediate.
Cross Reference Drug Bank:
DB09069
Gene Ontology Go:
intracellular membrane-bounded organelle
membrane
peroxisomal matrix
peroxisome
acetyl-CoA C-acyltransferase activity
palmitoyl-CoA oxidase activity
alpha-linolenic acid metabolic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
unsaturated fatty acid metabolic process
very long-chain fatty acid metabolic process
Gene Ontology Biological Process:
alpha-linolenic acid metabolic process
bile acid metabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA oxidase
small molecule metabolic process
unsaturated fatty acid metabolic process
very long-chain fatty acid metabolic process
Gene Ontology Molecular Function:
acetyl-CoA C-acyltransferase activity
palmitoyl-CoA oxidase activity
Gene Ontology Cellular Component:
intracellular membrane-bounded organelle
membrane
peroxisomal matrix
peroxisome
Keywords:
3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Fatty acid metabolism
Lipid metabolism
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transit peptide

Publication

PubMed ID:
3194209 2726492 1679347 16641997 15489334 19690332 21269460 24275569 25944712