Names & Taxonomy
- Uniprot ID:
- P09104
- Entry Name:
- ENOG_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)
- Gene Names:
- ENO2
- Gene Names Primary:
- ENO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 434
- Sequence:
- MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
- Pathway:
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
- Catalytic Activity:
- 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Mg(2+) is required for catalysis and for stabilizing the dimer.;
- Active Site:
- ACT_SITE 210 210 Proton donor.
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
myelin sheath
perikaryon
phosphopyruvate hydratase complex
photoreceptor inner segment
plasma membrane
magnesium ion binding
phosphopyruvate hydratase activity
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- magnesium ion binding
phosphopyruvate hydratase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space
myelin sheath
perikaryon
phosphopyruvate hydratase complex
photoreceptor inner segment
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Glycolysis
Lyase
Magnesium
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q9BSI4