Names & Taxonomy

Uniprot ID:
P08912
Entry Name:
ACM5_HUMAN
Status:
reviewed
Protein Names:
Muscarinic acetylcholine receptor M5
Gene Names:
CHRM5
Gene Names Primary:
CHRM5
Organism:
Homo sapiens (Human)

Structure

Length:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Function

Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Cross Reference Drug Bank:
DB08897 DB00321 DB00543 DB01238 DB00572 DB00835 DB01239 DB00568 DB00363 DB00785 DB00496 DB01151 DB01142 DB06702 DB00725 DB00458 DB01221 DB00408 DB00934 DB01403 DB00340 DB00622 DB00540 DB00334 DB00715 DB00454 DB00420 DB01069 DB00777 DB01224 DB00747 DB01591 DB01036 DB00376 DB00726 DB09076 DB00246
Gene Ontology Go:
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane
synapse
G-protein coupled acetylcholine receptor activity
phosphatidylinositol phospholipase C activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
dopamine transport
G-protein coupled acetylcholine receptor signaling pathway
gastric acid secretion
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of phosphatidylinositol dephosphorylation
synaptic transmission, cholinergic
transmission of nerve impulse
Gene Ontology Biological Process:
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
dopamine transport
gastric acid secretion
G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of phosphatidylinositol dephosphorylation
synaptic transmission, cholinergic
transmission of nerve impulse
Gene Ontology Molecular Function:
G-protein coupled acetylcholine receptor activity
phosphatidylinositol phospholipase C activity
Gene Ontology Cellular Component:
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane
synapse
Keywords:
Cell junction
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Synapse
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
3272174