Names & Taxonomy
- Uniprot ID:
- P08908
- Entry Name:
- 5HT1A_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A)
- Gene Names:
- HTR1A ADRB2RL1 ADRBRL1
- Gene Names Primary:
- HTR1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 422
- Sequence:
- MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
- Cross Reference Drug Bank:
- DB01614 DB00866 DB01616 DB00321 DB00543 DB00714 DB01238 DB06216 DB08807 DB09128 DB01200 DB00490 DB00248 DB06016 DB00477 DB08810 DB00363 DB01151 DB00988 DB01142 DB00216 DB01049 DB00696 DB04908 DB04946 DB00458 DB01221 DB00589 DB00408 DB08815 DB00247 DB06148 DB01618 DB00952 DB01149 DB00540 DB00334 DB00904 DB01267 DB01359 DB01186 DB00960 DB01621 DB00413 DB00571 DB01224 DB00734 DB00268 DB05271 DB00669 DB01622 DB00656 DB00726 DB06684 DB09068 DB01392 DB00246 DB00315
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled serotonin receptor activity
adenylate cyclase-inhibiting serotonin receptor signaling pathway
behavioral fear response
cell proliferation
exploration behavior
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
regulation of behavior
regulation of dopamine metabolic process
regulation of hormone secretion
regulation of serotonin secretion
serotonin metabolic process
serotonin receptor signaling pathway
vasoconstriction - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
behavioral fear response
cell proliferation
exploration behavior
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
regulation of behavior
regulation of dopamine metabolic process
regulation of hormone secretion
regulation of serotonin secretion
serotonin metabolic process
serotonin receptor signaling pathway
vasoconstriction - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Behavior
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- P11362