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Names & Taxonomy

Uniprot ID:: P08631
Entry Name:: HCK_HUMAN
Status:: reviewed
Protein Names:: Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene Names:: HCK
Gene Names Primary:: HCK
Organism:: Homo sapiens (Human)

Structure

Length:: 526
Sequence:: MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Isoform 1: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.; Isoform 2: Cell membrane

Function

Function:: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Catalytic Activity:: ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Enzyme Regulation:: ENZYME REGULATION: Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-411 is required for optimal activity. Phosphorylation at Tyr-522 inhibits kinase activity. Inhibited by PP1 and A-770041.
Active Site:: ACT_SITE 381 381 Proton acceptor.
Cross Reference Drug Bank:: DB06616
Gene Ontology Go:: caveola
cell projection
cytoskeleton
cytosol
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
Golgi apparatus
lysosome
nucleus
transport vesicle
ATP binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding
cell adhesion
cell differentiation
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
inflammatory response
innate immune response
innate immune response-activating signal transduction
integrin-mediated signaling pathway
interferon-gamma-mediated signaling pathway
leukocyte degranulation
leukocyte migration involved in immune response
lipopolysaccharide-mediated signaling pathway
mesoderm development
negative regulation of apoptotic process
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of actin cytoskeleton reorganization
positive regulation of actin filament polymerization
positive regulation of cell proliferation
protein autophosphorylation
protein phosphorylation
regulation of cell shape
regulation of defense response to virus by virus
regulation of inflammatory response
regulation of phagocytosis
regulation of podosome assembly
regulation of sequence-specific DNA binding transcription factor activity
respiratory burst after phagocytosis
transmembrane receptor protein tyrosine kinase signaling pathway
viral process
Gene Ontology Biological Process:: cell adhesion
cell differentiation
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
inflammatory response
innate immune response
innate immune response-activating signal transduction
integrin-mediated signaling pathway
interferon-gamma-mediated signaling pathway
leukocyte degranulation
leukocyte migration involved in immune response
lipopolysaccharide-mediated signaling pathway
mesoderm development
negative regulation of apoptotic process
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of actin cytoskeleton reorganization
positive regulation of actin filament polymerization
positive regulation of cell proliferation
protein autophosphorylation
protein phosphorylation
regulation of cell shape
regulation of defense response to virus by virus
regulation of inflammatory response
regulation of phagocytosis
regulation of podosome assembly
regulation of sequence-specific DNA binding transcription factor activity
respiratory burst after phagocytosis
transmembrane receptor protein tyrosine kinase signaling pathway
viral process
Gene Ontology Molecular Function:: ATP binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding
Gene Ontology Cellular Component:: caveola
cell projection
cytoskeleton
cytosol
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
Golgi apparatus
lysosome
nucleus
transport vesicle
Keywords:: 3D-structure
ATP-binding
Alternative initiation
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Exocytosis
Golgi apparatus
Host-virus interaction
Immunity
Inflammatory response
Innate immunity
Kinase
Lipoprotein
Lysosome
Membrane
Myristate
Nucleotide-binding
Nucleus
Palmitate
Phagocytosis
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase
Ubl conjugation
Interacts With:: O92972; P27958; Q13444; P09917; Q9ULH1; P22681; P00533; Q92556; P21860; P17948; O43559; Q9HD26; Q07666; P10721; Q6A162; P60411; Q5JR59; Q90VU7; Q7Z3S9; Q8TAK6; Q13177; Q8WUM4; P42338; Q92569; P19174; Q05397; Q07889; P12504; P42768; O43516

Names & Taxonomy

Structure

Subcellular location

Function

Publication