Names & Taxonomy
- Uniprot ID:
- P08620
- Entry Name:
- FGF4_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibroblast growth factor 4 (FGF-4) (Heparin secretory-transforming protein 1) (HST) (HST-1) (HSTF-1) (Heparin-binding growth factor 4) (HBGF-4) (Transforming protein KS3)
- Gene Names:
- FGF4 HST HSTF1 KS3
- Gene Names Primary:
- FGF4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 206
- Sequence:
- MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
- Cross Reference Drug Bank:
- DB00686
- Gene Ontology Go:
- extracellular region
intracellular
growth factor activity
heparin binding
activation of MAPKK activity
apoptotic process involved in morphogenesis
axon guidance
cartilage condensation
cell-cell signaling
chondroblast differentiation
cranial suture morphogenesis
embryonic hindlimb morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
mesenchymal cell proliferation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
odontogenesis of dentin-containing tooth
phosphatidylinositol-mediated signaling
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of transcription from RNA polymerase II promoter
Ras protein signal transduction
regulation of endothelial cell chemotaxis to fibroblast growth factor
signal transduction
small GTPase mediated signal transduction
stem cell population maintenance
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
apoptotic process involved in morphogenesis
axon guidance
cartilage condensation
cell-cell signaling
chondroblast differentiation
cranial suture morphogenesis
embryonic hindlimb morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
mesenchymal cell proliferation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
odontogenesis of dentin-containing tooth
phosphatidylinositol-mediated signaling
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of transcription from RNA polymerase II promoter
Ras protein signal transduction
regulation of endothelial cell chemotaxis to fibroblast growth factor
signal transduction
small GTPase mediated signal transduction
stem cell population maintenance
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- growth factor activity
heparin binding - Gene Ontology Cellular Component:
- extracellular region
intracellular - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Growth factor
Heparin-binding
Mitogen
Proto-oncogene
Reference proteome
Secreted
Signal