Names & Taxonomy
- Uniprot ID:
- P08588
- Entry Name:
- ADRB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)
- Gene Names:
- ADRB1 ADRB1R B1AR
- Gene Names Primary:
- ADRB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 477
- Sequence:
- MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
Function
- Function:
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
- Cross Reference Drug Bank:
- DB01193 DB00866 DB01118 DB00321 DB00182 DB01102 DB06216 DB00335 DB00195 DB00217 DB01295 DB00612 DB08807 DB08808 DB00248 DB00521 DB01136 DB04846 DB01407 DB01151 DB00841 DB04855 DB06262 DB01363 DB00668 DB00187 DB01288 DB00221 DB01064 DB00598 DB01210 DB00408 DB01365 DB01214 DB00264 DB00370 DB01203 DB04861 DB00368 DB00540 DB00334 DB01580 DB01359 DB00397 DB00960 DB01291 DB01297 DB00571 DB00852 DB01001 DB00489 DB00373 DB00726 DB09068
- Gene Ontology Go:
- early endosome
integral component of plasma membrane
plasma membrane
alpha-2A adrenergic receptor binding
beta-adrenergic receptor activity
beta1-adrenergic receptor activity
epinephrine binding
norepinephrine binding
PDZ domain binding
protein heterodimerization activity
Ras guanyl-nucleotide exchange factor activity
receptor signaling protein activity
activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
brown fat cell differentiation
cell-cell signaling
diet induced thermogenesis
fear response
heat generation
negative regulation of multicellular organism growth
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
response to cold
temperature homeostasis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
brown fat cell differentiation
cell-cell signaling
diet induced thermogenesis
fear response
heat generation
negative regulation of multicellular organism growth
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
response to cold
temperature homeostasis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure - Gene Ontology Molecular Function:
- alpha-2A adrenergic receptor binding
beta1-adrenergic receptor activity
beta-adrenergic receptor activity
epinephrine binding
norepinephrine binding
PDZ domain binding
protein heterodimerization activity
Ras guanyl-nucleotide exchange factor activity
receptor signaling protein activity - Gene Ontology Cellular Component:
- early endosome
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q86UL8; Q5TCQ9; P14270