Names & Taxonomy

Uniprot ID:
P08575
Entry Name:
PTPRC_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
Gene Names:
PTPRC CD45
Gene Names Primary:
PTPRC
Organism:
Homo sapiens (Human)

Structure

Length:
1304
Sequence:
MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 851 851 Phosphocysteine intermediate.; ACT_SITE 1167 1167 Phosphocysteine intermediate.
Gene Ontology Go:
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
intracellular
membrane
membrane raft
plasma membrane
protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
axon guidance
B cell proliferation
B cell receptor signaling pathway
bone marrow development
cell cycle phase transition
cell surface receptor signaling pathway
defense response to virus
dephosphorylation
hematopoietic progenitor cell differentiation
immunoglobulin biosynthetic process
negative regulation of cell adhesion involved in substrate-bound cell migration
negative regulation of cytokine-mediated signaling pathway
negative regulation of protein kinase activity
negative regulation of T cell mediated cytotoxicity
peptidyl-tyrosine dephosphorylation
positive regulation of antigen receptor-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of hematopoietic stem cell migration
positive regulation of protein kinase activity
positive regulation of stem cell proliferation
positive regulation of T cell proliferation
protein dephosphorylation
regulation of cell cycle
release of sequestered calcium ion into cytosol
stem cell development
T cell differentiation
T cell receptor signaling pathway
Gene Ontology Biological Process:
axon guidance
B cell proliferation
B cell receptor signaling pathway
bone marrow development
cell cycle phase transition
cell surface receptor signaling pathway
defense response to virus
dephosphorylation
hematopoietic progenitor cell differentiation
immunoglobulin biosynthetic process
negative regulation of cell adhesion involved in substrate-bound cell migration
negative regulation of cytokine-mediated signaling pathway
negative regulation of protein kinase activity
negative regulation of T cell mediated cytotoxicity
peptidyl-tyrosine dephosphorylation
positive regulation of antigen receptor-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of hematopoietic stem cell migration
positive regulation of protein kinase activity
positive regulation of stem cell proliferation
positive regulation of T cell proliferation
protein dephosphorylation
regulation of cell cycle
release of sequestered calcium ion into cytosol
stem cell development
T cell differentiation
T cell receptor signaling pathway
Gene Ontology Molecular Function:
protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
intracellular
membrane
membrane raft
plasma membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Repeat
SCID
Signal
Transmembrane
Transmembrane helix
Interacts With:
P41240; P35222; P04626; P20701; P06239; P06240; P09382; Q02763

Publication

PubMed ID:
2824653 2956090 14702039 2531281 2971730 2845400 1695146 11909961 12676959 19367720 19159218 19349973 19690332 21269460 22174689 25944712 15684325 11101853 11145714 16959974