Names & Taxonomy
- Uniprot ID:
- P08575
- Entry Name:
- PTPRC_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
- Gene Names:
- PTPRC CD45
- Gene Names Primary:
- PTPRC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1304
- Sequence:
- MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 851 851 Phosphocysteine intermediate.; ACT_SITE 1167 1167 Phosphocysteine intermediate.
- Gene Ontology Go:
- cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
intracellular
membrane
membrane raft
plasma membrane
protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
axon guidance
B cell proliferation
B cell receptor signaling pathway
bone marrow development
cell cycle phase transition
cell surface receptor signaling pathway
defense response to virus
dephosphorylation
hematopoietic progenitor cell differentiation
immunoglobulin biosynthetic process
negative regulation of cell adhesion involved in substrate-bound cell migration
negative regulation of cytokine-mediated signaling pathway
negative regulation of protein kinase activity
negative regulation of T cell mediated cytotoxicity
peptidyl-tyrosine dephosphorylation
positive regulation of antigen receptor-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of hematopoietic stem cell migration
positive regulation of protein kinase activity
positive regulation of stem cell proliferation
positive regulation of T cell proliferation
protein dephosphorylation
regulation of cell cycle
release of sequestered calcium ion into cytosol
stem cell development
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Biological Process:
- axon guidance
B cell proliferation
B cell receptor signaling pathway
bone marrow development
cell cycle phase transition
cell surface receptor signaling pathway
defense response to virus
dephosphorylation
hematopoietic progenitor cell differentiation
immunoglobulin biosynthetic process
negative regulation of cell adhesion involved in substrate-bound cell migration
negative regulation of cytokine-mediated signaling pathway
negative regulation of protein kinase activity
negative regulation of T cell mediated cytotoxicity
peptidyl-tyrosine dephosphorylation
positive regulation of antigen receptor-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of hematopoietic stem cell migration
positive regulation of protein kinase activity
positive regulation of stem cell proliferation
positive regulation of T cell proliferation
protein dephosphorylation
regulation of cell cycle
release of sequestered calcium ion into cytosol
stem cell development
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- protein kinase binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
intracellular
membrane
membrane raft
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Repeat
SCID
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P41240; P35222; P04626; P20701; P06239; P06240; P09382; Q02763