Names & Taxonomy
- Uniprot ID:
- P08514
- Entry Name:
- ITA2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
- Gene Names:
- ITGA2B GP2B ITGAB
- Gene Names Primary:
- ITGA2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1039
- Sequence:
- MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
- Cross Reference Drug Bank:
- DB00054 DB00775
- Gene Ontology Go:
- blood microparticle
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
integrin complex
plasma membrane
platelet alpha granule membrane
extracellular matrix binding
identical protein binding
metal ion binding
axon guidance
blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
integrin-mediated signaling pathway
platelet activation
platelet aggregation
platelet degranulation
positive regulation of leukocyte migration - Gene Ontology Biological Process:
- axon guidance
blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
integrin-mediated signaling pathway
platelet activation
platelet aggregation
platelet degranulation
positive regulation of leukocyte migration - Gene Ontology Molecular Function:
- extracellular matrix binding
identical protein binding
metal ion binding - Gene Ontology Cellular Component:
- blood microparticle
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integral component of plasma membrane
integrin complex
plasma membrane
platelet alpha granule membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Integrin
Membrane
Metal-binding
Polymorphism
Pyrrolidone carboxylic acid
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Itself; P05106
Publication
- PubMed ID:
- 2439501 2345548 2322558 14702039 16625196 15489334 2351656 3422188 3479442 2845986 3534886 1953640 8620874 3801670 2476117 2775232 7688323 9809974 2226834 9030514 10477286 10212286 16335952 18331836 21388953 22779914 22283712 7878622 2350579 8282784 7508443 7706461 8704171 9215749 9473221 9763559 9834222 9722314 9734640 10391209 9920835 10607701 11798398 12181054 12083483 12424194 12506038 15099289 15219201 17018384 20020534 21454453