Names & Taxonomy
- Uniprot ID:
- P08243
- Entry Name:
- ASNS_HUMAN
- Status:
- reviewed
- Protein Names:
- Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase)
- Gene Names:
- ASNS TS11
- Gene Names Primary:
- ASNS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 561
- Sequence:
- MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
- Proteomes:
- UP000005640
Function
- Pathway:
- Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.
- Catalytic Activity:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.
- Active Site:
- ACT_SITE 2 2 For GATase activity.
- Cross Reference Drug Bank:
- DB00171 DB00174 DB00128 DB00130
- Gene Ontology Go:
- cytosol
asparagine synthase (glutamine-hydrolyzing) activity
ATP binding
cofactor binding
protein homodimerization activity
asparagine biosynthetic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
cellular protein metabolic process
cellular response to glucose starvation
cellular response to hormone stimulus
endoplasmic reticulum unfolded protein response
glutamine metabolic process
L-asparagine biosynthetic process
liver development
negative regulation of apoptotic process
PERK-mediated unfolded protein response
positive regulation of mitotic cell cycle
response to amino acid
response to follicle-stimulating hormone
response to light stimulus
response to mechanical stimulus
response to methotrexate
response to toxic substance
small molecule metabolic process - Gene Ontology Biological Process:
- asparagine biosynthetic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
cellular protein metabolic process
cellular response to glucose starvation
cellular response to hormone stimulus
endoplasmic reticulum unfolded protein response
glutamine metabolic process
L-asparagine biosynthetic process
liver development
negative regulation of apoptotic process
PERK-mediated unfolded protein response
positive regulation of mitotic cell cycle
response to amino acid
response to follicle-stimulating hormone
response to light stimulus
response to mechanical stimulus
response to methotrexate
response to toxic substance
small molecule metabolic process - Gene Ontology Molecular Function:
- asparagine synthase (glutamine-hydrolyzing) activity
ATP binding
cofactor binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- ATP-binding
Acetylation
Alternative splicing
Amino-acid biosynthesis
Asparagine biosynthesis
Complete proteome
Disease mutation
Glutamine amidotransferase
Ligase
Mental retardation
Nucleotide-binding
Polymorphism
Reference proteome - Interacts With:
- Q86WT6; A2RRH5