Names & Taxonomy
- Uniprot ID:
- P08238
- Entry Name:
- HS90B_HUMAN
- Status:
- reviewed
- Protein Names:
- Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)
- Gene Names:
- HSP90AB1 HSP90B HSPC2 HSPCB
- Gene Names Primary:
- HSP90AB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Function
- Function:
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
cytoplasm
cytosol
extracellular exosome
inclusion body
melanosome
membrane
mitochondrion
nucleoplasm
ATP binding
CTP binding
dATP binding
double-stranded RNA binding
GTP binding
histone deacetylase binding
kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
poly(A) RNA binding
protein kinase regulator activity
TPR domain binding
UTP binding
axon guidance
cellular response to heat
cellular response to interleukin-4
cellular response to organic cyclic compound
Fc-gamma receptor signaling pathway involved in phagocytosis
fibril organization
innate immune response
negative regulation of neuron apoptotic process
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
placenta development
positive regulation of cell size
positive regulation of nitric oxide biosynthetic process
positive regulation of protein binding
positive regulation of protein import into nucleus, translocation
positive regulation of protein serine/threonine kinase activity
protein folding
regulation of cellular response to heat
regulation of interferon-gamma-mediated signaling pathway
regulation of protein ubiquitination
regulation of type I interferon-mediated signaling pathway
response to salt stress
response to unfolded protein
virion attachment to host cell - Gene Ontology Biological Process:
- axon guidance
cellular response to heat
cellular response to interleukin-4
cellular response to organic cyclic compound
Fc-gamma receptor signaling pathway involved in phagocytosis
fibril organization
innate immune response
negative regulation of neuron apoptotic process
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
placenta development
positive regulation of cell size
positive regulation of nitric oxide biosynthetic process
positive regulation of protein binding
positive regulation of protein import into nucleus, translocation
positive regulation of protein serine/threonine kinase activity
protein folding
regulation of cellular response to heat
regulation of interferon-gamma-mediated signaling pathway
regulation of protein ubiquitination
regulation of type I interferon-mediated signaling pathway
response to salt stress
response to unfolded protein
virion attachment to host cell - Gene Ontology Molecular Function:
- ATP binding
CTP binding
dATP binding
double-stranded RNA binding
GTP binding
histone deacetylase binding
kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
poly(A) RNA binding
protein kinase regulator activity
TPR domain binding
UTP binding - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
cytoplasm
cytosol
extracellular exosome
inclusion body
melanosome
membrane
mitochondrion
nucleoplasm - Keywords:
- 3D-structure
ATP-binding
Acetylation
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Glycoprotein
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
S-nitrosylation
Stress response
Ubl conjugation - Interacts With:
- P36896; Q9UL18; O95433; O00170; P31751; Q9UM73; Q16671; P10398; Q96GD4; P15056; Q06187; Q13555; Q16543; Q7L3B6; Q15131; O94921; Q96Q40; P11802; Q00534; P50750; O14757; Q9UHD1; P49674; Q13618; Q16832; P00533; P29317; P04626; P21860; Q15303; Q96A26; Q9UKC9; O75426; Q9UKT8; P22607; P09769; P21333; P35916; P06241; Q8TF76; P49840; Q9UPZ9; O14920; Q14164; Q9Y6K9; Q2WGJ6; P06239; P53671; Q99558; P41279; P80192; P31152; P10636-8; P42679; O15146; Q8TD19; P19838; O75469; Q9P215; Q13131; P22694; Q02156; Q05513; Q15139; P51817; P11801; P04049; P49758; Q01974; Q15418; Q15831; Q15208; Q9UNE7; Q9Y2Z0-2; Q9UHD2; Q96S53; Q9BXA6; P29597; Q8IWX7
Publication
- PubMed ID:
- 3301534 2768249 2469626 11230166 14702039 14574404 15489334 2492519 8180474 9150948 9482106 16139798 15592455 17081983 17081065 16478993 17525332 18042044 18620420 18088087 18669648 18318008 19696785 19608861 20068231 21269460 21908771 21406692 22828320 24275569 24681825 25944712 15217611 15159550