Names & Taxonomy

Uniprot ID:
P08100
Entry Name:
OPSD_HUMAN
Status:
reviewed
Protein Names:
Rhodopsin (Opsin-2)
Gene Names:
RHO OPN2
Gene Names Primary:
RHO
Organism:
Homo sapiens (Human)

Structure

Length:
348
Sequence:
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
Cross Reference Drug Bank:
DB01159
Gene Ontology Go:
cell-cell junction
ciliary membrane
Golgi apparatus
Golgi membrane
Golgi-associated vesicle membrane
integral component of plasma membrane
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor inner segment membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
rough endoplasmic reticulum membrane
G-protein coupled receptor activity
metal ion binding
photoreceptor activity
retinal binding
absorption of visible light
G-protein coupled receptor signaling pathway
organelle organization
photoreceptor cell maintenance
phototransduction, visible light
protein phosphorylation
protein-chromophore linkage
red, far-red light phototransduction
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
retinoid metabolic process
rhodopsin mediated signaling pathway
visual perception
Gene Ontology Biological Process:
absorption of visible light
G-protein coupled receptor signaling pathway
organelle organization
photoreceptor cell maintenance
phototransduction, visible light
protein-chromophore linkage
protein phosphorylation
red, far-red light phototransduction
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
retinoid metabolic process
rhodopsin mediated signaling pathway
visual perception
Gene Ontology Molecular Function:
G-protein coupled receptor activity
metal ion binding
photoreceptor activity
retinal binding
Gene Ontology Cellular Component:
cell-cell junction
ciliary membrane
Golgi apparatus
Golgi-associated vesicle membrane
Golgi membrane
integral component of plasma membrane
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor inner segment membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
rough endoplasmic reticulum membrane
Keywords:
3D-structure
Acetylation
Chromophore
Complete proteome
Congenital stationary night blindness
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Metal-binding
Palmitate
Phosphoprotein
Photoreceptor protein
Polymorphism
Receptor
Reference proteome
Retinal protein
Retinitis pigmentosa
Sensory transduction
Transducer
Transmembrane
Transmembrane helix
Vision
Zinc
Interacts With:
O95405

Publication

PubMed ID:
6589631 17974005 15489334 8566799 8401533 2239971 2137202 2215617 1985460 1897520 1840561 1862076 1833777 1302614 1391967 8317502 8353500 8358437 8088850 8076945 7981701 7987326 7987331 8081400 8045708 7987385 7633434 7846071 8554077 9452035 9888392 19934218 19960070 22334370