Names & Taxonomy
- Uniprot ID:
- P08100
- Entry Name:
- OPSD_HUMAN
- Status:
- reviewed
- Protein Names:
- Rhodopsin (Opsin-2)
- Gene Names:
- RHO OPN2
- Gene Names Primary:
- RHO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 348
- Sequence:
- MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
- Cross Reference Drug Bank:
- DB01159
- Gene Ontology Go:
- cell-cell junction
ciliary membrane
Golgi apparatus
Golgi membrane
Golgi-associated vesicle membrane
integral component of plasma membrane
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor inner segment membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
rough endoplasmic reticulum membrane
G-protein coupled receptor activity
metal ion binding
photoreceptor activity
retinal binding
absorption of visible light
G-protein coupled receptor signaling pathway
organelle organization
photoreceptor cell maintenance
phototransduction, visible light
protein phosphorylation
protein-chromophore linkage
red, far-red light phototransduction
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
retinoid metabolic process
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Biological Process:
- absorption of visible light
G-protein coupled receptor signaling pathway
organelle organization
photoreceptor cell maintenance
phototransduction, visible light
protein-chromophore linkage
protein phosphorylation
red, far-red light phototransduction
regulation of rhodopsin mediated signaling pathway
retina development in camera-type eye
retinoid metabolic process
rhodopsin mediated signaling pathway
visual perception - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
metal ion binding
photoreceptor activity
retinal binding - Gene Ontology Cellular Component:
- cell-cell junction
ciliary membrane
Golgi apparatus
Golgi-associated vesicle membrane
Golgi membrane
integral component of plasma membrane
photoreceptor disc membrane
photoreceptor inner segment
photoreceptor inner segment membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
rough endoplasmic reticulum membrane - Keywords:
- 3D-structure
Acetylation
Chromophore
Complete proteome
Congenital stationary night blindness
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Metal-binding
Palmitate
Phosphoprotein
Photoreceptor protein
Polymorphism
Receptor
Reference proteome
Retinal protein
Retinitis pigmentosa
Sensory transduction
Transducer
Transmembrane
Transmembrane helix
Vision
Zinc - Interacts With:
- O95405