Names & Taxonomy
- Uniprot ID:
- P07996
- Entry Name:
- TSP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Thrombospondin-1
- Gene Names:
- THBS1 TSP TSP1
- Gene Names Primary:
- THBS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1170
- Sequence:
- MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
- Gene Ontology Go:
- cell surface
endoplasmic reticulum
endoplasmic reticulum lumen
external side of plasma membrane
extracellular exosome
extracellular matrix
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule
platelet alpha granule lumen
sarcoplasmic reticulum
secretory granule
calcium ion binding
collagen V binding
fibrinogen binding
fibroblast growth factor binding
fibronectin binding
glycoprotein binding
heparin binding
identical protein binding
integrin binding
laminin binding
low-density lipoprotein particle binding
phosphatidylserine binding
proteoglycan binding
transforming growth factor beta binding
activation of MAPK activity
behavioral response to pain
blood coagulation
cell adhesion
cell cycle arrest
cell migration
cellular protein metabolic process
cellular response to heat
chronic inflammatory response
engulfment of apoptotic cell
extracellular matrix organization
immune response
inflammatory response
negative regulation of angiogenesis
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of apoptotic process
negative regulation of blood vessel endothelial cell migration
negative regulation of cell-matrix adhesion
negative regulation of cGMP-mediated signaling
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of dendritic cell antigen processing and presentation
negative regulation of endothelial cell chemotaxis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of fibrinolysis
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of focal adhesion assembly
negative regulation of interleukin-12 production
negative regulation of nitric oxide mediated signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of plasminogen activation
peptide cross-linking
platelet activation
platelet degranulation
positive regulation of angiogenesis
positive regulation of blood coagulation
positive regulation of blood vessel endothelial cell migration
positive regulation of cell migration
positive regulation of chemotaxis
positive regulation of endothelial cell apoptotic process
positive regulation of endothelial cell migration
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of fibroblast migration
positive regulation of macrophage activation
positive regulation of macrophage chemotaxis
positive regulation of phosphorylation
positive regulation of protein kinase B signaling
positive regulation of reactive oxygen species metabolic process
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of transforming growth factor beta1 production
positive regulation of translation
positive regulation of tumor necrosis factor biosynthetic process
post-translational protein modification
protein O-linked fucosylation
protein O-linked glycosylation
regulation of cGMP metabolic process
response to calcium ion
response to drug
response to endoplasmic reticulum stress
response to glucose
response to hypoxia
response to magnesium ion
response to progesterone
response to unfolded protein
sprouting angiogenesis - Gene Ontology Biological Process:
- activation of MAPK activity
behavioral response to pain
blood coagulation
cell adhesion
cell cycle arrest
cell migration
cellular protein metabolic process
cellular response to heat
chronic inflammatory response
engulfment of apoptotic cell
extracellular matrix organization
immune response
inflammatory response
negative regulation of angiogenesis
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of apoptotic process
negative regulation of blood vessel endothelial cell migration
negative regulation of cell-matrix adhesion
negative regulation of cGMP-mediated signaling
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of dendritic cell antigen processing and presentation
negative regulation of endothelial cell chemotaxis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of fibrinolysis
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of focal adhesion assembly
negative regulation of interleukin-12 production
negative regulation of nitric oxide mediated signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of plasminogen activation
peptide cross-linking
platelet activation
platelet degranulation
positive regulation of angiogenesis
positive regulation of blood coagulation
positive regulation of blood vessel endothelial cell migration
positive regulation of cell migration
positive regulation of chemotaxis
positive regulation of endothelial cell apoptotic process
positive regulation of endothelial cell migration
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of fibroblast migration
positive regulation of macrophage activation
positive regulation of macrophage chemotaxis
positive regulation of phosphorylation
positive regulation of protein kinase B signaling
positive regulation of reactive oxygen species metabolic process
positive regulation of transforming growth factor beta1 production
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of translation
positive regulation of tumor necrosis factor biosynthetic process
post-translational protein modification
protein O-linked fucosylation
protein O-linked glycosylation
regulation of cGMP metabolic process
response to calcium ion
response to drug
response to endoplasmic reticulum stress
response to glucose
response to hypoxia
response to magnesium ion
response to progesterone
response to unfolded protein
sprouting angiogenesis - Gene Ontology Molecular Function:
- calcium ion binding
collagen V binding
fibrinogen binding
fibroblast growth factor binding
fibronectin binding
glycoprotein binding
heparin binding
identical protein binding
integrin binding
laminin binding
low-density lipoprotein particle binding
phosphatidylserine binding
proteoglycan binding
transforming growth factor beta binding - Gene Ontology Cellular Component:
- cell surface
endoplasmic reticulum
endoplasmic reticulum lumen
external side of plasma membrane
extracellular exosome
extracellular matrix
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule
platelet alpha granule lumen
sarcoplasmic reticulum
secretory granule - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Glycoprotein
Heparin-binding
Polymorphism
Reference proteome
Repeat
Sarcoplasmic reticulum
Signal
Unfolded protein response - Interacts With:
- Q15113; P01137