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Names & Taxonomy

Uniprot ID:: P07948
Entry Name:: LYN_HUMAN
Status:: reviewed
Protein Names:: Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene Names:: LYN JTK8
Gene Names Primary:: LYN
Organism:: Homo sapiens (Human)

Structure

Length:: 512
Sequence:: MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane

Function

Function:: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Catalytic Activity:: ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Enzyme Regulation:: ENZYME REGULATION: Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656.
Active Site:: ACT_SITE 367 367 Proton acceptor.
Cross Reference Drug Bank:: DB06616 DB09079 DB08901
Gene Ontology Go:: cell-cell adherens junction
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
Golgi apparatus
integrin alpha2-beta1 complex
mast cell granule
membrane raft
mitochondrial crista
mitochondrial intermembrane space
nucleus
perinuclear region of cytoplasm
plasma membrane
postsynaptic density
ATP binding
enzyme binding
glycosphingolipid binding
ion channel binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding
receptor signaling protein tyrosine kinase activity
adaptive immune response
axon guidance
B cell homeostasis
B cell receptor signaling pathway
blood coagulation
cellular response to DNA damage stimulus
cellular response to extracellular stimulus
cellular response to heat
cellular response to retinoic acid
cytokine secretion
dendritic cell differentiation
ephrin receptor signaling pathway
erythrocyte differentiation
Fc receptor mediated inhibitory signaling pathway
Fc receptor mediated stimulatory signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
histamine secretion by mast cell
immune response-regulating cell surface receptor signaling pathway
innate immune response
JAK-STAT cascade involved in growth hormone signaling pathway
leukocyte migration
lipopolysaccharide-mediated signaling pathway
negative regulation of B cell proliferation
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of immune response
negative regulation of intracellular signal transduction
negative regulation of MAP kinase activity
negative regulation of mast cell proliferation
negative regulation of myeloid leukocyte differentiation
negative regulation of protein phosphorylation
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
neuron projection development
oligodendrocyte development
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
platelet activation
platelet degranulation
positive regulation of B cell receptor signaling pathway
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cellular component movement
positive regulation of dendritic cell apoptotic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of glial cell proliferation
positive regulation of mast cell proliferation
positive regulation of neuron projection development
positive regulation of oligodendrocyte progenitor proliferation
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of tyrosine phosphorylation of STAT protein
protein autophosphorylation
protein phosphorylation
regulation of B cell apoptotic process
regulation of B cell receptor signaling pathway
regulation of cell adhesion mediated by integrin
regulation of cytokine production
regulation of cytokine secretion
regulation of ERK1 and ERK2 cascade
regulation of erythrocyte differentiation
regulation of inflammatory response
regulation of mast cell activation
regulation of mast cell degranulation
regulation of monocyte chemotaxis
regulation of platelet aggregation
regulation of protein phosphorylation
regulation of release of sequestered calcium ion into cytosol
response to amino acid
response to axon injury
response to carbohydrate
response to drug
response to hormone
response to insulin
response to organic cyclic compound
response to sterol depletion
response to toxic substance
signal transduction
signal transduction by protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
T cell costimulation
tolerance induction to self antigen
transmembrane receptor protein tyrosine kinase signaling pathway
viral process
Gene Ontology Biological Process:: adaptive immune response
axon guidance
B cell homeostasis
B cell receptor signaling pathway
blood coagulation
cellular response to DNA damage stimulus
cellular response to extracellular stimulus
cellular response to heat
cellular response to retinoic acid
cytokine secretion
dendritic cell differentiation
ephrin receptor signaling pathway
erythrocyte differentiation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated inhibitory signaling pathway
Fc receptor mediated stimulatory signaling pathway
histamine secretion by mast cell
immune response-regulating cell surface receptor signaling pathway
innate immune response
JAK-STAT cascade involved in growth hormone signaling pathway
leukocyte migration
lipopolysaccharide-mediated signaling pathway
negative regulation of B cell proliferation
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of immune response
negative regulation of intracellular signal transduction
negative regulation of MAP kinase activity
negative regulation of mast cell proliferation
negative regulation of myeloid leukocyte differentiation
negative regulation of protein phosphorylation
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
neuron projection development
oligodendrocyte development
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
platelet activation
platelet degranulation
positive regulation of B cell receptor signaling pathway
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of cellular component movement
positive regulation of dendritic cell apoptotic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of glial cell proliferation
positive regulation of mast cell proliferation
positive regulation of neuron projection development
positive regulation of oligodendrocyte progenitor proliferation
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of tyrosine phosphorylation of STAT protein
protein autophosphorylation
protein phosphorylation
regulation of B cell apoptotic process
regulation of B cell receptor signaling pathway
regulation of cell adhesion mediated by integrin
regulation of cytokine production
regulation of cytokine secretion
regulation of ERK1 and ERK2 cascade
regulation of erythrocyte differentiation
regulation of inflammatory response
regulation of mast cell activation
regulation of mast cell degranulation
regulation of monocyte chemotaxis
regulation of platelet aggregation
regulation of protein phosphorylation
regulation of release of sequestered calcium ion into cytosol
response to amino acid
response to axon injury
response to carbohydrate
response to drug
response to hormone
response to insulin
response to organic cyclic compound
response to sterol depletion
response to toxic substance
signal transduction
signal transduction by protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
T cell costimulation
tolerance induction to self antigen
transmembrane receptor protein tyrosine kinase signaling pathway
viral process
Gene Ontology Molecular Function:: ATP binding
enzyme binding
glycosphingolipid binding
ion channel binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
receptor binding
receptor signaling protein tyrosine kinase activity
Gene Ontology Cellular Component:: cell-cell adherens junction
cytoplasm
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
Golgi apparatus
integrin alpha2-beta1 complex
mast cell granule
membrane raft
mitochondrial crista
mitochondrial intermembrane space
nucleus
perinuclear region of cytoplasm
plasma membrane
postsynaptic density
Keywords:: 3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Golgi apparatus
Host-virus interaction
Immunity
Inflammatory response
Innate immunity
Kinase
Lipoprotein
Membrane
Myristate
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase
Ubl conjugation
Interacts With:: O92972; P22575; P27958; Q9WMX2; P10275; Q8R5G7; P20273; P25063; P11049; P46527; P00533; Q13480; P63244; Q9HCN6; P05556; P10721; P33993; P08581; Q9NWQ8; P12931

Names & Taxonomy

Structure

Subcellular location

Function

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