Names & Taxonomy
- Uniprot ID:
- P07900
- Entry Name:
- HS90A_HUMAN
- Status:
- reviewed
- Protein Names:
- Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
- Gene Names:
- HSP90AA1 HSP90A HSPC1 HSPCA
- Gene Names Primary:
- HSP90AA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 732
- Sequence:
- MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Function
- Function:
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
- Cross Reference Drug Bank:
- DB00716 DB00615
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
cytoplasm
cytosol
endocytic vesicle lumen
extracellular exosome
extracellular matrix
extracellular region
lysosomal lumen
melanosome
membrane
myelin sheath
neuron projection
neuronal cell body
nucleoplasm
nucleus
perinuclear region of cytoplasm
plasma membrane
protein complex
ruffle membrane
ATP binding
ATPase activity
CTP binding
dATP binding
GTP binding
GTPase binding
histone deacetylase binding
identical protein binding
MHC class II protein complex binding
mRNA binding
nitric-oxide synthase regulator activity
nucleotide binding
poly(A) RNA binding
protein homodimerization activity
TPR domain binding
UTP binding
axon guidance
cardiac muscle cell apoptotic process
cellular response to heat
chaperone-mediated autophagy
chaperone-mediated protein complex assembly
Fc-gamma receptor signaling pathway involved in phagocytosis
G2/M transition of mitotic cell cycle
innate immune response
mitochondrial transport
mitotic cell cycle
neuron migration
nitric oxide metabolic process
organelle organization
positive regulation of cardiac muscle contraction
positive regulation of cell size
positive regulation of lamellipodium assembly
positive regulation of nitric oxide biosynthetic process
positive regulation of protein import into nucleus, translocation
protein import into mitochondrial outer membrane
protein refolding
protein unfolding
receptor-mediated endocytosis
regulation of cellular response to heat
regulation of nitric-oxide synthase activity
regulation of protein complex assembly
regulation of protein ubiquitination
response to antibiotic
response to cold
response to estrogen
response to heat
response to salt stress
response to unfolded protein
signal transduction
skeletal muscle contraction
small molecule metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- axon guidance
cardiac muscle cell apoptotic process
cellular response to heat
chaperone-mediated autophagy
chaperone-mediated protein complex assembly
Fc-gamma receptor signaling pathway involved in phagocytosis
G2/M transition of mitotic cell cycle
innate immune response
mitochondrial transport
mitotic cell cycle
neuron migration
nitric oxide metabolic process
organelle organization
positive regulation of cardiac muscle contraction
positive regulation of cell size
positive regulation of lamellipodium assembly
positive regulation of nitric oxide biosynthetic process
positive regulation of protein import into nucleus, translocation
protein import into mitochondrial outer membrane
protein refolding
protein unfolding
receptor-mediated endocytosis
regulation of cellular response to heat
regulation of nitric-oxide synthase activity
regulation of protein complex assembly
regulation of protein ubiquitination
response to antibiotic
response to cold
response to estrogen
response to heat
response to salt stress
response to unfolded protein
signal transduction
skeletal muscle contraction
small molecule metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
CTP binding
dATP binding
GTPase binding
GTP binding
histone deacetylase binding
identical protein binding
MHC class II protein complex binding
mRNA binding
nitric-oxide synthase regulator activity
nucleotide binding
poly(A) RNA binding
protein homodimerization activity
TPR domain binding
UTP binding - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
cytoplasm
cytosol
endocytic vesicle lumen
extracellular exosome
extracellular matrix
extracellular region
lysosomal lumen
melanosome
membrane
myelin sheath
neuronal cell body
neuron projection
nucleoplasm
nucleus
perinuclear region of cytoplasm
plasma membrane
protein complex
ruffle membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell membrane
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
S-nitrosylation
Stress response
Ubl conjugation - Interacts With:
- Itself; O95433; Q8IWD4; Q16543; Q7L3B6; P50750; Q96G23; Q9UHD1; O15111; P00533; P04626; Q02790; Q14318; Q6PK50; Q9Y6K9; P05412; O43318-2; P04150; P26882; P53041; Q15185; Q9H6T3; P61247; P35467; Q15831; Q9UNE7
Publication
- PubMed ID:
- 2780322 1368637 2527334 16269234 14702039 12508121 2469626 2591742 15489334 2492519 10409742 15937123 2507541 8289821 7588731 9195923 9660753 10508479 11274138 11583998 11276205 12853476 12604615 15235609 15383005 15577939 17081983 16807684 16531226 19367720 18088087 18691976 18669648 18318008 19413330 19690332 19608861 19875381 16139798 17081065 17028174 18256191 19696785 20068231 21269460 21406692 24275569 24681825 25944712 9108479 9817749 16307917