Names & Taxonomy
- Uniprot ID:
- P07858
- Entry Name:
- CATB_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
- Gene Names:
- CTSB CPSB
- Gene Names Primary:
- CTSB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 339
- Sequence:
- MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome. Melanosome. Secreted, extracellular space
Function
- Function:
- Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
- Catalytic Activity:
- Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
- Active Site:
- ACT_SITE 108 108; ACT_SITE 278 278; ACT_SITE 298 298
- Gene Ontology Go:
- apical plasma membrane
caveola
endolysosome lumen
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
intracellular
intracellular membrane-bounded organelle
lysosome
melanosome
mitochondrion
nucleolus
perinuclear region of cytoplasm
sarcolemma
collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
peptidase activity
peptide binding
proteoglycan binding
autophagy
cellular response to mechanical stimulus
cellular response to thyroid hormone stimulus
collagen catabolic process
decidualization
epithelial cell differentiation
extracellular matrix disassembly
extracellular matrix organization
innate immune response
negative regulation of cell death
proteolysis
proteolysis involved in cellular protein catabolic process
regulation of apoptotic process
regulation of catalytic activity
response to amine
response to ethanol
response to glucose
response to interleukin-4
response to organic cyclic compound
response to peptide hormone
response to wounding
skeletal muscle tissue development
spermatogenesis
toll-like receptor signaling pathway
viral entry into host cell - Gene Ontology Biological Process:
- autophagy
cellular response to mechanical stimulus
cellular response to thyroid hormone stimulus
collagen catabolic process
decidualization
epithelial cell differentiation
extracellular matrix disassembly
extracellular matrix organization
innate immune response
negative regulation of cell death
proteolysis
proteolysis involved in cellular protein catabolic process
regulation of apoptotic process
regulation of catalytic activity
response to amine
response to ethanol
response to glucose
response to interleukin-4
response to organic cyclic compound
response to peptide hormone
response to wounding
skeletal muscle tissue development
spermatogenesis
toll-like receptor signaling pathway
viral entry into host cell - Gene Ontology Molecular Function:
- collagen binding
cysteine-type endopeptidase activity
cysteine-type peptidase activity
peptidase activity
peptide binding
proteoglycan binding - Gene Ontology Cellular Component:
- apical plasma membrane
caveola
endolysosome lumen
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
intracellular
intracellular membrane-bounded organelle
lysosome
melanosome
mitochondrion
nucleolus
perinuclear region of cytoplasm
sarcolemma - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Protease
Reference proteome
Secreted
Signal
Thiol protease
Zymogen - Interacts With:
- Q6UY14; P02760; P40692; Q9NYA1