Names & Taxonomy

Uniprot ID:
P07741
Entry Name:
APT_HUMAN
Status:
reviewed
Protein Names:
Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)
Gene Names:
APRT
Gene Names Primary:
APRT
Organism:
Homo sapiens (Human)

Structure

Length:
180
Sequence:
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Pathway:
Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Catalytic Activity:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Cross Reference Drug Bank:
DB00173 DB00131
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
adenine binding
adenine phosphoribosyltransferase activity
AMP binding
adenine salvage
AMP salvage
cellular response to insulin stimulus
grooming behavior
lactation
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine-containing compound salvage
small molecule metabolic process
Gene Ontology Biological Process:
adenine salvage
AMP salvage
cellular response to insulin stimulus
grooming behavior
lactation
nucleobase-containing small molecule metabolic process
purine-containing compound salvage
purine nucleobase metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
adenine binding
adenine phosphoribosyltransferase activity
AMP binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycosyltransferase
Phosphoprotein
Polymorphism
Purine salvage
Reference proteome
Transferase

Publication

PubMed ID:
3684585 3554238 17974005 15616553 15489334 3531209 12665801 19413330 19369195 19608861 21269460 22223895 22814378 24275569 25944712 15196008 1746557 7915931 3680503 3343350 1353080 11243733 15571218 21635362