Names & Taxonomy
- Uniprot ID:
- P07741
- Entry Name:
- APT_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)
- Gene Names:
- APRT
- Gene Names Primary:
- APRT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 180
- Sequence:
- MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
- Pathway:
- Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
- Catalytic Activity:
- AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
- Cross Reference Drug Bank:
- DB00173 DB00131
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
adenine binding
adenine phosphoribosyltransferase activity
AMP binding
adenine salvage
AMP salvage
cellular response to insulin stimulus
grooming behavior
lactation
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine-containing compound salvage
small molecule metabolic process - Gene Ontology Biological Process:
- adenine salvage
AMP salvage
cellular response to insulin stimulus
grooming behavior
lactation
nucleobase-containing small molecule metabolic process
purine-containing compound salvage
purine nucleobase metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- adenine binding
adenine phosphoribosyltransferase activity
AMP binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycosyltransferase
Phosphoprotein
Polymorphism
Purine salvage
Reference proteome
Transferase