Names & Taxonomy

Uniprot ID:
P07686
Entry Name:
HEXB_HUMAN
Status:
reviewed
Protein Names:
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Gene Names:
HEXB HCC7
Gene Names Orf:
HCC7
Gene Names Primary:
HEXB
Organism:
Homo sapiens (Human)

Structure

Length:
556
Sequence:
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome.

Function

Function:
Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
Catalytic Activity:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Active Site:
ACT_SITE 355 355 Proton donor.
Gene Ontology Go:
acrosomal vesicle
azurophil granule
extracellular exosome
lysosomal lumen
membrane
acetylglucosaminyltransferase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity
astrocyte cell migration
carbohydrate metabolic process
cellular calcium ion homeostasis
cellular protein metabolic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
ganglioside catabolic process
glycosaminoglycan metabolic process
glycosphingolipid metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
lipid storage
locomotory behavior
lysosome organization
male courtship behavior
myelination
neuromuscular process controlling balance
oligosaccharide catabolic process
oogenesis
penetration of zona pellucida
phospholipid biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
regulation of cell shape
sensory perception of sound
skeletal system development
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Biological Process:
astrocyte cell migration
carbohydrate metabolic process
cellular calcium ion homeostasis
cellular protein metabolic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
ganglioside catabolic process
glycosaminoglycan metabolic process
glycosphingolipid metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
lipid storage
locomotory behavior
lysosome organization
male courtship behavior
myelination
neuromuscular process controlling balance
oligosaccharide catabolic process
oogenesis
penetration of zona pellucida
phospholipid biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
regulation of cell shape
sensory perception of sound
skeletal system development
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Molecular Function:
acetylglucosaminyltransferase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity
Gene Ontology Cellular Component:
acrosomal vesicle
azurophil granule
extracellular exosome
lysosomal lumen
membrane
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Gangliosidosis
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Neurodegeneration
Polymorphism
Reference proteome
Signal
Zymogen

Publication

PubMed ID:
3013851 2977375 2964638 15372022 15489334 2971039 2147427 2966076 2139028 2525487 2965147 2579389 2971395 12754519 11447134 19159218 21269460 24275569 25944712 8673609 12662933 12706724 1825792 1720305 1531140 8357844 7626071 7557963 7633435 8950198 9401004 9856491 9694901