Names & Taxonomy
- Uniprot ID:
- P07686
- Entry Name:
- HEXB_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
- Gene Names:
- HEXB HCC7
- Gene Names Orf:
- HCC7
- Gene Names Primary:
- HEXB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 556
- Sequence:
- MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
- Catalytic Activity:
- Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
- Active Site:
- ACT_SITE 355 355 Proton donor.
- Gene Ontology Go:
- acrosomal vesicle
azurophil granule
extracellular exosome
lysosomal lumen
membrane
acetylglucosaminyltransferase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity
astrocyte cell migration
carbohydrate metabolic process
cellular calcium ion homeostasis
cellular protein metabolic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
ganglioside catabolic process
glycosaminoglycan metabolic process
glycosphingolipid metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
lipid storage
locomotory behavior
lysosome organization
male courtship behavior
myelination
neuromuscular process controlling balance
oligosaccharide catabolic process
oogenesis
penetration of zona pellucida
phospholipid biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
regulation of cell shape
sensory perception of sound
skeletal system development
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- astrocyte cell migration
carbohydrate metabolic process
cellular calcium ion homeostasis
cellular protein metabolic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
ganglioside catabolic process
glycosaminoglycan metabolic process
glycosphingolipid metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
lipid storage
locomotory behavior
lysosome organization
male courtship behavior
myelination
neuromuscular process controlling balance
oligosaccharide catabolic process
oogenesis
penetration of zona pellucida
phospholipid biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
regulation of cell shape
sensory perception of sound
skeletal system development
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- acetylglucosaminyltransferase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity - Gene Ontology Cellular Component:
- acrosomal vesicle
azurophil granule
extracellular exosome
lysosomal lumen
membrane - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Gangliosidosis
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Neurodegeneration
Polymorphism
Reference proteome
Signal
Zymogen