Names & Taxonomy
- Uniprot ID:
- P07602
- Entry Name:
- SAP_HUMAN
- Status:
- reviewed
- Protein Names:
- Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
- Gene Names:
- PSAP GLBA SAP1
- Gene Names Primary:
- PSAP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Function:
- Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of membrane
lysosomal lumen
lysosomal membrane
mitochondrion
enzyme activator activity
G-protein coupled receptor binding
lipid binding
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood coagulation
cellular response to organic substance
epithelial cell differentiation involved in prostate gland development
glycosphingolipid metabolic process
lipid transport
negative regulation of hydrogen peroxide-induced cell death
platelet activation
platelet degranulation
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
regulation of autophagy
regulation of lipid metabolic process
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood coagulation
cellular response to organic substance
epithelial cell differentiation involved in prostate gland development
glycosphingolipid metabolic process
lipid transport
negative regulation of hydrogen peroxide-induced cell death
platelet activation
platelet degranulation
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
regulation of autophagy
regulation of lipid metabolic process
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- enzyme activator activity
G-protein coupled receptor binding
lipid binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of membrane
lysosomal lumen
lysosomal membrane
mitochondrion - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Gangliosidosis
Gaucher disease
Glycoprotein
Leukodystrophy
Lipid metabolism
Lysosome
Metachromatic leukodystrophy
Reference proteome
Repeat
Secreted
Signal
Sphingolipid metabolism - Interacts With:
- P31944
Publication
- PubMed ID:
- 2515150 2498298 15164054 15489334 2842863 1612590 8323276 1958198 2013321 2717620 8370464 2825202 2868718 3242555 2209618 3442600 2845979 3048308 10562467 7730378 10383054 10510427 11180632 10406958 14657016 12510003 19167329 19159218 21269460 21835174 24275569 25944712 12518053 7866401 2302219 2320574 2019586 1371116 2060627 10196694 10682309 11309366 15773042 17919309