Names & Taxonomy
- Uniprot ID:
- P07585
- Entry Name:
- PGS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Decorin (Bone proteoglycan II) (PG-S2) (PG40)
- Gene Names:
- DCN SLRR1B
- Gene Names Primary:
- DCN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- May affect the rate of fibrils formation.
- Cross Reference Drug Bank:
- DB03754
- Gene Ontology Go:
- collagen type VI trimer
cytoplasm
extracellular region
extracellular space
Golgi lumen
lysosomal lumen
extracellular matrix binding
glycosaminoglycan binding
poly(A) RNA binding
protein kinase inhibitor activity
aging
carbohydrate metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
cytokine-mediated signaling pathway
dermatan sulfate biosynthetic process
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
kidney development
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of JAK-STAT cascade
negative regulation of protein kinase activity
negative regulation of vascular endothelial growth factor signaling pathway
organ morphogenesis
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
placenta development
positive regulation of autophagy
positive regulation of macroautophagy
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of transcription from RNA polymerase II promoter
response to lipopolysaccharide
response to mechanical stimulus
skeletal muscle tissue development
small molecule metabolic process
wound healing - Gene Ontology Biological Process:
- aging
carbohydrate metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
chondroitin sulfate metabolic process
cytokine-mediated signaling pathway
dermatan sulfate biosynthetic process
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
kidney development
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of JAK-STAT cascade
negative regulation of protein kinase activity
negative regulation of vascular endothelial growth factor signaling pathway
organ morphogenesis
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
placenta development
positive regulation of autophagy
positive regulation of macroautophagy
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of transcription from RNA polymerase II promoter
response to lipopolysaccharide
response to mechanical stimulus
skeletal muscle tissue development
small molecule metabolic process
wound healing - Gene Ontology Molecular Function:
- extracellular matrix binding
glycosaminoglycan binding
poly(A) RNA binding
protein kinase inhibitor activity - Gene Ontology Cellular Component:
- collagen type VI trimer
cytoplasm
extracellular region
extracellular space
Golgi lumen
lysosomal lumen - Keywords:
- Alternative splicing
Complete proteome
Corneal dystrophy
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Polymorphism
Proteoglycan
Reference proteome
Repeat
Secreted
Signal