Names & Taxonomy
- Uniprot ID:
- P07451
- Entry Name:
- CAH3_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III)
- Gene Names:
- CA3
- Gene Names Primary:
- CA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 260
- Sequence:
- MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=52.0 mM for CO(2)
- Enzyme Regulation:
- ENZYME REGULATION: Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by coumarins and sulfonamide derivatives such as acetazolamide.
- Active Site:
- ACT_SITE 127 127
- Cross Reference Drug Bank:
- DB00819 DB00909
- Gene Ontology Go:
- cytosol
carbonate dehydratase activity
nickel cation binding
phosphatase activity
zinc ion binding
bicarbonate transport
one-carbon metabolic process
response to ethanol
response to oxidative stress
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
one-carbon metabolic process
response to ethanol
response to oxidative stress
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
nickel cation binding
phosphatase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Glutathionylation
Lyase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Zinc