Names & Taxonomy
- Uniprot ID:
- P07384
- Entry Name:
- CAN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
- Gene Names:
- CAPN1 CANPL1 PIG30
- Gene Names Orf:
- PIG30
- Gene Names Primary:
- CAPN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 714
- Sequence:
- MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
- Catalytic Activity:
- Broad endopeptidase specificity.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 4 Ca(2+) ions.;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
- Active Site:
- ACT_SITE 115 115
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
focal adhesion
lysosome
membrane
mitochondrion
plasma membrane
calcium ion binding
calcium-dependent cysteine-type endopeptidase activity
extracellular matrix disassembly
extracellular matrix organization
mammary gland involution
positive regulation of cell proliferation
protein autoprocessing
proteolysis
receptor catabolic process
regulation of macroautophagy - Gene Ontology Biological Process:
- extracellular matrix disassembly
extracellular matrix organization
mammary gland involution
positive regulation of cell proliferation
protein autoprocessing
proteolysis
receptor catabolic process
regulation of macroautophagy - Gene Ontology Molecular Function:
- calcium-dependent cysteine-type endopeptidase activity
calcium ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
focal adhesion
lysosome
membrane
mitochondrion
plasma membrane - Keywords:
- 3D-structure
Acetylation
Autocatalytic cleavage
Calcium
Cell membrane
Complete proteome
Cytoplasm
Hydrolase
Membrane
Metal-binding
Polymorphism
Protease
Reference proteome
Repeat
Thiol protease - Interacts With:
- P15311; P18031; P40763