Names & Taxonomy
- Uniprot ID:
- P07204
- Entry Name:
- TRBM_HUMAN
- Status:
- reviewed
- Protein Names:
- Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
- Gene Names:
- THBD THRM
- Gene Names Primary:
- THBD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 575
- Sequence:
- MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
- Cross Reference Drug Bank:
- DB00055 DB01050
- Gene Ontology Go:
- cell surface
extracellular space
integral component of plasma membrane
plasma membrane
calcium ion binding
receptor activity
transmembrane signaling receptor activity
blood coagulation
female pregnancy
leukocyte migration
negative regulation of blood coagulation
negative regulation of fibrinolysis
negative regulation of platelet activation
response to cAMP
response to lipopolysaccharide
response to X-ray - Gene Ontology Biological Process:
- blood coagulation
female pregnancy
leukocyte migration
negative regulation of blood coagulation
negative regulation of fibrinolysis
negative regulation of platelet activation
response to cAMP
response to lipopolysaccharide
response to X-ray - Gene Ontology Molecular Function:
- calcium ion binding
receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- cell surface
extracellular space
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Hemolytic uremic syndrome
Hemostasis
Hydroxylation
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Thrombophilia
Transmembrane
Transmembrane helix - Interacts With:
- P00734