Names & Taxonomy
- Uniprot ID:
- P07195
- Entry Name:
- LDHB_HUMAN
- Status:
- reviewed
- Protein Names:
- L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)
- Gene Names:
- LDHB
- Gene Names Primary:
- LDHB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 334
- Sequence:
- MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Pathway:
- Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
- Catalytic Activity:
- (S)-lactate + NAD(+) = pyruvate + NADH.
- Active Site:
- ACT_SITE 194 194 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
membrane raft
mitochondrion
myelin sheath
L-lactate dehydrogenase activity
NAD binding
carbohydrate metabolic process
cellular metabolic process
lactate metabolic process
NAD metabolic process
pyruvate metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular metabolic process
lactate metabolic process
NAD metabolic process
pyruvate metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- L-lactate dehydrogenase activity
NAD binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane
membrane raft
mitochondrion
myelin sheath - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- P00338-3; Q5S007; P50542; P54274