Names & Taxonomy
- Uniprot ID:
- P07108
- Entry Name:
- ACBP_HUMAN
- Status:
- reviewed
- Protein Names:
- Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)
- Gene Names:
- DBI
- Gene Names Primary:
- DBI
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 87
- Sequence:
- MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
- Gene Ontology Go:
- endoplasmic reticulum
extracellular exosome
Golgi apparatus
perinuclear endoplasmic reticulum
benzodiazepine receptor binding
lipid binding
long-chain fatty acyl-CoA binding
protein dimerization activity
phosphatidylcholine acyl-chain remodeling
transport - Gene Ontology Biological Process:
- phosphatidylcholine acyl-chain remodeling
transport - Gene Ontology Molecular Function:
- benzodiazepine receptor binding
lipid binding
long-chain fatty acyl-CoA binding
protein dimerization activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
extracellular exosome
Golgi apparatus
perinuclear endoplasmic reticulum - Keywords:
- 3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Golgi apparatus
Lipid-binding
Phosphoprotein
Polymorphism
Reference proteome
Transport