Names & Taxonomy
- Uniprot ID:
- P06870
- Entry Name:
- KLK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
- Gene Names:
- KLK1
- Gene Names Primary:
- KLK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 262
- Sequence:
- MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
- Proteomes:
- UP000005640
Function
- Function:
- Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
- Catalytic Activity:
- Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
- Active Site:
- ACT_SITE 65 65 Charge relay system.; ACT_SITE 120 120 Charge relay system.; ACT_SITE 214 214 Charge relay system.
- Cross Reference Drug Bank:
- DB06692
- Gene Ontology Go:
- extracellular exosome
nucleus
serine-type endopeptidase activity - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
- Gene Ontology Cellular Component:
- extracellular exosome
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Zymogen