Names & Taxonomy

Uniprot ID:
P06870
Entry Name:
KLK1_HUMAN
Status:
reviewed
Protein Names:
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
Gene Names:
KLK1
Gene Names Primary:
KLK1
Organism:
Homo sapiens (Human)

Structure

Length:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
Proteomes:
UP000005640

Function

Function:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Catalytic Activity:
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
Active Site:
ACT_SITE 65 65 Charge relay system.; ACT_SITE 120 120 Charge relay system.; ACT_SITE 214 214 Charge relay system.
Cross Reference Drug Bank:
DB06692
Gene Ontology Go:
extracellular exosome
nucleus
serine-type endopeptidase activity
Gene Ontology Molecular Function:
serine-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Zymogen

Publication

PubMed ID:
3004571 2898948 2686621 7749372 11006094 11054574 15057824 15489334 3853975 3163150 2666327 393608 3635530 15651049 11912256 15765151